Recombinant Human SMCP protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SMCP also known as sperm mitochondria-associated cysteine-rich protein is a protein with a mass of approximately 11 kDa. It is expressed mainly in the sperm mitochondria playing a role in mitochondrial dynamics and structure specific to sperm cells. SMCP exhibits a cysteine-rich composition which contributes to its structural properties facilitating its mechanical functions within the mitochondrial compartment.

Biological function summary

Sperm mitochondria-associated cysteine-rich protein contributes to sperm motility and energy management. This protein plays a role in stabilizing mitochondrial morphology and energy metabolism which impacts sperm functionality. It doesn't engage directly in larger protein complexes; however it influences mitochondrial integrity and activity essential for effective fertilization processes. SMCP supports the structural stability of mitochondria enabling efficient spermatogenesis and spermatozoa function.

Pathways

SMCP integrates into pathways governing mitochondrial dynamics and bioenergetics. It participates particularly in the oxidative phosphorylation pathway pivotal for ATP generation within sperm cells. SMCP functionally interacts with proteins such as ATP5B a vital component of the ATP synthase complex indicating its involvement in energy production critical for sperm movement and fertility.

Defects in SMCP have links to male infertility and asthenozoospermia a condition characterized by reduced sperm motility. SMCP's association with mitochondrial abnormalities suggests a connection to proteins involved in mitochondrial disorders such as MTFMT known for its role in mitochondrial translation. Understanding SMCP's function can provide insights into diagnosing and treating infertility issues related to compromised sperm motility.