Recombinant Human SMOC1 protein (His tag) is a Human Fragment protein, in the 1 to 435 aa range, expressed in HEK 293, with >92% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >92% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M L P A R C A R L L T P H L L L V L V Q L S P A R G H R T T G P R F L I S D R D P Q C N L H C S R T Q P K P I C A S D G R S Y E S M C E Y Q R A K C R D P T L G V V H R G R C K D A G Q S K C R L E R A Q A L E Q A K K P Q E A V F V P E C G E D G S F T Q V Q C H T Y T G Y C W C V T P D G K P I S G S S V Q N K T P V C S G S V T D K P L S Q G N S G R K D D G S K P T P T M E T Q P V F D G D E I T A P T L W I K H L V I K D S K L N N T N I R N S E K V Y S C D Q E R Q S A L E E A Q Q N P R E G I V I P E C A P G G L Y K P V Q C H Q S T G Y C W C V L V D T G R P L P G T S T R Y V M P S C E S D A R A K T T E A D D P F K D R E L P G C P E G K K M E F I T S L L D A L T T D M V Q A I N S A A P T G G G R F S E P D P S H T L E E R V V H W Y F S Q L D S N S S N D I N K R E M K P F K R Y V K K K A K P K K C A R R F T D Y C D L N K D K V I S L P E L K G C L G V S K E V G R L V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.
Alternative names
SPARC-related modular calcium-binding protein 1, Secreted modular calcium-binding protein 1, SMOC-1, SMOC1
Recommended products
Recombinant Human SMOC1 protein (His tag) is a Human Fragment protein, in the 1 to 435 aa range, expressed in HEK 293, with >92% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >92% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9H4F8-2
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M L P A R C A R L L T P H L L L V L V Q L S P A R G H R T T G P R F L I S D R D P Q C N L H C S R T Q P K P I C A S D G R S Y E S M C E Y Q R A K C R D P T L G V V H R G R C K D A G Q S K C R L E R A Q A L E Q A K K P Q E A V F V P E C G E D G S F T Q V Q C H T Y T G Y C W C V T P D G K P I S G S S V Q N K T P V C S G S V T D K P L S Q G N S G R K D D G S K P T P T M E T Q P V F D G D E I T A P T L W I K H L V I K D S K L N N T N I R N S E K V Y S C D Q E R Q S A L E E A Q Q N P R E G I V I P E C A P G G L Y K P V Q C H Q S T G Y C W C V L V D T G R P L P G T S T R Y V M P S C E S D A R A K T T E A D D P F K D R E L P G C P E G K K M E F I T S L L D A L T T D M V Q A I N S A A P T G G G R F S E P D P S H T L E E R V V H W Y F S Q L D S N S S N D I N K R E M K P F K R Y V K K K A K P K K C A R R F T D Y C D L N K D K V I S L P E L K G C L G V S K E V G R L V
- Accession
- Q9H4F8
- Protein length
- Fragment
- Predicted molecular weight
- 47 kDa
- Amino acids
- 1 to 435
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.
- Post-translational modifications
Glycosylated.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SPARC-related modular calcium binding 1 (SMOC1) is an extracellular matrix protein coded by the SMOC1 gene. Known also as its full form the protein weighs approximately 59 kDa and consists of several domains including a thyroglobulin type-1 repeat and two EF-hand domains. SMOC1 is widely expressed in various tissues such as the eye bone and skin. Its expression pattern suggests it plays an important role in tissue development and maintenance.
- Biological function summary
SMOC1 functions involve regulation of angiogenesis and cellular differentiation. It interacts with the extracellular matrix modulating the assembly and dynamics of structural proteins. SMOC1 sounds interactions with calmodulin and integrins forming part of a larger complex. This complex engagement influences cellular processes like cell migration adhesion and stabilization which are pivotal for development and wound healing.
- Pathways
SMOC1 associates with integrin signaling and TGF-beta signaling pathways. These pathways govern processes like cell growth apoptosis and differentiation. SMOC1 modulates the activity of integrins connecting with proteins such as integrin alpha-V beta-3 and transforming growth factor beta (TGF-β). Their relationships indicate SMOC1's involvement in cellular communication and response to environmental changes.
- Associated diseases and disorders
SMOC1 links to conditions like microphthalmia and coloboma as well as bone development disorders. Mutations or dysregulation of SMOC1 impairs normal development indicating its role in ocular and skeletal health. Researchers note connections with proteins like Pax6 which is also involved in eye development. This involvement shows how closely SMOC1 is tied to disorders affecting vision and structural integrity.
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1 product image
SDS-PAGE - Recombinant Human SMOC1 protein (His tag) (ab276453)
SDS-PAGE analysis of ab276453.
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