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AB276453

Recombinant Human SMOC1 protein (His tag)

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(1 Publication)

Recombinant Human SMOC1 protein (His tag) is a Human Fragment protein, in the 1 to 435 aa range, expressed in HEK 293 cells, with >92%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

SPARC-related modular calcium-binding protein 1, Secreted modular calcium-binding protein 1, SMOC-1, SMOC1

1 Images
SDS-PAGE - Recombinant Human SMOC1 protein (His tag) (AB276453)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SMOC1 protein (His tag) (AB276453)

SDS-PAGE analysis of ab276453.

Key facts

Purity

>92% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9H4F8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Complementary Products

Primary Antibodies

AB313569

Anti-SMOC1 antibody [EPR26922-29]

20ul selling size|RabMAb|KO Validated|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-SMOC1 antibody [EPR26922-29] (AB313569)

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Proteins & Peptides

AB269024

Recombinant Human Tau (phospho ) protein

SDS-PAGE - Recombinant Human Tau (phospho ) protein (AB269024)

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Assay Kits

AB309579

Human SMOC1 Antibody Pair - BSA and Azide free

RabMAb|Recombinant

Sandwich ELISA - Human SMOC1 Antibody Pair - BSA and Azide free (AB309579)

  • 0
  • 0
Assay Kits

AB315434

Human SMOC1 ELISA Kit

SimpleStep

Sandwich ELISA - Human SMOC1 ELISA Kit (AB315434)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MLPARCARLLTPHLLLVLVQLSPARGHRTTGPRFLISDRDPQCNLHCSRTQPKPICASDGRSYESMCEYQRAKCRDPTLGVVHRGRCKDAGQSKCRLERAQALEQAKKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGSVTDKPLSQGNSGRKDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNIRNSEKVYSCDQERQSALEEAQQNPREGIVIPECAPGGLYKPVQCHQSTGYCWCVLVDTGRPLPGTSTRYVMPSCESDARAKTTEADDPFKDRELPGCPEGKKMEFITSLLDALTTDMVQAINSAAPTGGGRFSEPDPSHTLEERVVHWYFSQLDSNSSNDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGCLGVSKEVGRLV","proteinLength":"Fragment","predictedMolecularWeight":"47 kDa","actualMolecularWeight":null,"aminoAcidEnd":435,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9H4F8","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SPARC-related modular calcium binding 1 (SMOC1) is an extracellular matrix protein coded by the SMOC1 gene. Known also as its full form the protein weighs approximately 59 kDa and consists of several domains including a thyroglobulin type-1 repeat and two EF-hand domains. SMOC1 is widely expressed in various tissues such as the eye bone and skin. Its expression pattern suggests it plays an important role in tissue development and maintenance.
Biological function summary

SMOC1 functions involve regulation of angiogenesis and cellular differentiation. It interacts with the extracellular matrix modulating the assembly and dynamics of structural proteins. SMOC1 sounds interactions with calmodulin and integrins forming part of a larger complex. This complex engagement influences cellular processes like cell migration adhesion and stabilization which are pivotal for development and wound healing.

Pathways

SMOC1 associates with integrin signaling and TGF-beta signaling pathways. These pathways govern processes like cell growth apoptosis and differentiation. SMOC1 modulates the activity of integrins connecting with proteins such as integrin alpha-V beta-3 and transforming growth factor beta (TGF-β). Their relationships indicate SMOC1's involvement in cellular communication and response to environmental changes.

SMOC1 links to conditions like microphthalmia and coloboma as well as bone development disorders. Mutations or dysregulation of SMOC1 impairs normal development indicating its role in ocular and skeletal health. Researchers note connections with proteins like Pax6 which is also involved in eye development. This involvement shows how closely SMOC1 is tied to disorders affecting vision and structural integrity.
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Specifications

Form

Lyophilized

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General info

Function

Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.

Post-translational modifications

Glycosylated.

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Product protocols

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Target data

Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.
See full target information SMOC1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Acta neuropathologica 148:72 PubMed39585417

2024

SMOC1 colocalizes with Alzheimer's disease neuropathology and delays Aβ aggregation.

Applications

Unspecified application

Species

Unspecified reactive species

Kaleah Balcomb,Caitlin Johnston,Tomas Kavanagh,Dominique Leitner,Julie Schneider,Glenda Halliday,Thomas Wisniewski,Margaret Sunde,Eleanor Drummond
View all publications
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Product promise

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