Recombinant Human SMP30 protein (denatured)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SMP30 also known as senescence marker protein-30 or regucalcin functions as a calcium-binding protein involved in calcium homeostasis and antioxidation. SMP30's molecular mass is approximately 36 kDa reflecting its role in cellular maintenance processes. The protein exhibits expression in various tissues including liver kidney brain and lung reflecting its diverse functional roles within the body. SMP30 displays a strong presence in these tissues indicating its involvement in essential cellular mechanisms.

Biological function summary

SMP30 contributes to cellular longevity and protection against oxidative stress. This protein participates in several mechanisms that support cellular senescence and aging processes. SMP30 is part of a family of proteins that control intracellular calcium levels an important factor in cellular signaling and function. By maintaining calcium balance SMP30 enhances cell health and survival especially under conditions that challenge cellular stability.

Pathways

SMP30 plays important roles in the calcium signaling pathway and the oxidative stress response pathway. Within these pathways SMP30 interacts with proteins such as calmodulin and superoxide dismutase. Calmodulin links to calcium signaling while superoxide dismutase addresses oxidative stress management. These interactions place SMP30 centrally within pathways that govern cellular response to physiological and environmental changes.

SMP30 associates with aging-related disorders like osteoporosis and neurodegeneration. Changes in SMP30 expression correlate with altered calcium homeostasis contributing to these conditions. In the context of neurodegeneration SMP30's calcium-binding ability interacts with proteins such as calcium/calmodulin-dependent protein kinase a regulator in neuronal survival and plasticity. Understanding SMP30’s role provides insights into therapeutic avenues especially for diseases where calcium dysregulation and oxidative stress play an important part.