Recombinant Human SMR3B protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SMR3B also known as submaxillary gland androgen-regulated protein 3B is a protein with a molecular mass of approximately 12 kDa. It is primarily expressed in the salivary glands particularly in the submandibular gland. SMR3B is believed to act as a secretory protein contributing to glandular functions. This protein is regulated by androgens indicating a role in modulating responses based on hormonal signals.

Biological function summary

SMR3B contributes to maintaining fluid and protein balance within the glandular secretions. SMR3B is not currently known to be a part of a larger protein complex indicating it may function independently. Its expression level might change in response to physiological states influenced by androgens suggesting a role in adaptive processes within the salivary glands. The protein may also aid in protecting mucosal surfaces by interacting with other secreted factors.

Pathways

Glandular secretions and hormonal signaling are key areas where SMR3B might exert its effects. It might participate in pathways involved in endocrine regulation due to its androgen-responsive nature. SMR3B's relationship with androgens connects it to hormone-specific signaling pathways potentially involving other proteins like androgen receptor (AR) that modulates responses to androgens in various tissues.

Altered SMR3B levels or function could impact disorders associated with salivary gland function or hormonal imbalances. For instance it may have implications in sialadenitis due to its role in glandular secretions. Additionally any dysfunction in androgen signaling where this protein might play a part could link it to conditions such as androgenic alopecia. The interplay with androgen receptor proteins highlights its potential relevance in situations where androgen levels are disrupted.