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AB187424

Recombinant Human SNAPC1 protein (denatured)

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Recombinant Human SNAPC1 protein (denatured) is a Human Full Length protein, in the 1 to 368 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

View Alternative Names

SNAP43, SNAPC1, snRNA-activating protein complex subunit 1, SNAPc subunit 1, Proximal sequence element-binding transcription factor subunit gamma, Small nuclear RNA-activating complex polypeptide 1, snRNA-activating protein complex 43 kDa subunit, PSE-binding factor subunit gamma, PTF subunit gamma, SNAPc 43 kDa subunit

1 Images
SDS-PAGE - Recombinant Human SNAPC1 protein (denatured) (AB187424)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SNAPC1 protein (denatured) (AB187424)

15% SDS-PAGE analysis of ab187424 (3μg).

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q16533

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as SNAP43
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMGTPPGLQTDCEALLSRFQETDSVRFEDFTELWRNMKFGTIFCGRMRNLEKNMFTKEALALAWRYFLPPYTFQIRVGALYLLYGLYNTQLCQPKQKIRVALKDWDEVLKFQQDLVNAQHFDAAYIFRKLRLDRAFHFTAMPKLLSYRMKKKIHRAEVTEEFKDPSDRVMKLITSDVLEEMLNVHDHYQNMKHVISVDKSKPDKALSLIKDDFFDNIKNIVLEHQQWHKDRKNPSLKSKTNDGEEKMEGNSQETERCERAESLAKIKSKAFSVVIQASKSRRHRQVKLDSSDSDSASGQGQVKATRKKEKKERLKPAGRKMSLRNKGNVQNIHKEDKPLSLSMPVITEEEENESLSGTEFTASKKRRKH","proteinLength":"Full Length","predictedMolecularWeight":"45.44 kDa","actualMolecularWeight":null,"aminoAcidEnd":368,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q16533","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SNAPC1 also known as small nuclear RNA activating complex polypeptide 1 is a component of the snRNA-activating protein complex. It has a mass of about 43 kDa. SNAPC1 plays an important role in the transcription initiation of small nuclear RNA (snRNA) genes. It functions through interaction with other components of the SNAPc complex. Researchers observe its expression in various tissues but it appears particularly active in cells with high transcriptional demand.
Biological function summary

The role of SNAPC1 lies in the assembly and regulation of the SNAPc complex. This complex functions primarily in the transcription of snRNA essential for mRNA processing and gene expression regulation. By participating in the formation of the snRNA-activating protein complex SNAPC1 facilitates the correct transcription and processing of snRNA a critical component in the spliceosomal machinery. It achieves this by forming stable interactions with other SNAPc components including SNAPC2 and SNAPC3 contributing to pre-mRNA splicing.

Pathways

SNAPC1 integrates into two major cellular pathways: transcription initiation and RNA splicing. It closely interacts with elements such as RNA polymerase II and SNAPC4 within these pathways. By securing a stable interaction with these elements SNAPC1 supports efficient transcription of snRNA and its subsequent processing. The proper function of SNAPC1 and related proteins ensures the accuracy of mRNA splicing impacting overall gene expression and cellular function.

Defects or dysregulations involving SNAPC1 can link to disorders like Spinal Muscular Atrophy (SMA) and systemic lupus erythematosus (SLE). In SMA disruptions in snRNA processing lead to defects in the creation of essential proteins needed for motor neuron survival wherein SNAPC1 may hold a supporting role. In SLE abnormal snRNA processing can contribute to the production of autoantibodies linking SNAPC1 to the autoimmune pathway. SNAPC1's functional interactions with proteins like SMN (Survival of Motor Neuron) protein in SMA further illustrate its involvement in these disorders.
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Specifications

Form

Liquid

Additional notes

ab187424 is purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20 mM Tris pH 7.5, 2 mM EDTA.

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General info

Function

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
See full target information SNAPC1
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Product promise

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