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AB204151

Recombinant human SNRK protein (Active)

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Recombinant human SNRK protein (Active) is a Human Full Length protein, in the 1 to 765 aa range, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE, FuncS.

View Alternative Names

KIAA0096, SNFRK, SNRK, SNF-related serine/threonine-protein kinase, SNF1-related kinase

4 Images
Functional Studies - Recombinant human SNRK protein (Active) (AB204151)
  • FuncS

Unknown

Functional Studies - Recombinant human SNRK protein (Active) (AB204151)

The specific activity of SNRK (ab204151) was determined to be 14 nmol/min/mg as per activity assay protocol

SDS-PAGE - Recombinant human SNRK protein (Active) (AB204151)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant human SNRK protein (Active) (AB204151)

SDS PAGE analysis of ab204151

Functional Studies - Recombinant human SNRK protein (Active) (AB204151)
  • FuncS

Supplier Data

Functional Studies - Recombinant human SNRK protein (Active) (AB204151)

The specific activity of SNRK was determined to be 16 nmol/min/mg.

SDS-PAGE - Recombinant human SNRK protein (Active) (AB204151)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human SNRK protein (Active) (AB204151)

SDS-PAGE analysis of ab204151 which was determined to be >80% pure by densitometry.

Key facts

Purity

>80% Densitometry

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

Specific activity is 16 nmol/min/mg.

Accession

Q9NRH2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHGSTKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELERIKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI","proteinLength":"Full Length","predictedMolecularWeight":"110 kDa","actualMolecularWeight":null,"aminoAcidEnd":765,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q9NRH2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SNRK also known as SNF-related kinase is a serine/threonine protein kinase with a molecular mass of approximately 80 kDa. It is part of the AMPK-related kinases family. This kinase is expressed in a wide range of tissues including heart muscle and adipose tissue. SNRK plays a role in various cellular processes by phosphorylating target proteins influencing their activity and function in the cell.
Biological function summary

Through phosphorylation SNRK controls energy balance and cellular stress responses. It does not function as part of a large protein complex but can interact with other proteins to modulate metabolic processes. SNRK contributes to regulating cell growth apoptosis and metabolism. It has a significant role in maintaining energy homeostasis and responding to nutrient availability potentially affecting metabolic syndrome.

Pathways

SNRK participates in energy-sensing pathways. It plays an important role alongside AMP-activated protein kinase (AMPK) involved in response to cellular energy levels. SNRK is also linked to the insulin signaling pathway which regulates glucose metabolism. Its activity impacts downstream targets such as acetyl-CoA carboxylase an important enzyme related to fatty acid metabolism. This indicates SNRK's importance in pathways influencing metabolic health and organism energy status.

SNRK has shown connections to metabolic disorders and cardiovascular diseases. It emerges as a potential player in the development of type 2 diabetes which involves disrupted energy regulation. Similarly in cardiovascular diseases SNRK interacts with proteins such as AMP-activated protein kinase highlighting its role in cardiac function and health. Understanding SNRK's regulation might offer insights into therapeutic strategies for these conditions.
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Specifications

Form

Liquid

Additional notes

Purity was determined to be >80% by densitometry. Affinity purified.

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General info

Function

May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Post-translational modifications

Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.

Subcellular localisation

Nucleus

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.
See full target information SNRK
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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