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AB107134

Recombinant Human SNRPB2 protein

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Recombinant Human SNRPB2 protein is a Human Full Length protein, in the 1 to 225 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

U2 small nuclear ribonucleoprotein B'', U2 snRNP B'', SNRPB2

1 Images
SDS-PAGE - Recombinant Human SNRPB2 protein (AB107134)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human SNRPB2 protein (AB107134)

15% SDS-PAGE showing ab107134 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P08579

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 40% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMDIRPNHTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALKTMKMRGQAFVIFKELGSSTNALRQLQGFPFYGKPMRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANTQGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAKK","proteinLength":"Full Length","predictedMolecularWeight":"27.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":225,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P08579","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SNRPB2 also known as small nuclear ribonucleoprotein polypeptide B' is a protein that plays a role in the splicing of pre-mRNA. It often weighs around 25 kDa and is expressed in the nucleus of cells. The protein is a component of the spliceosome which is an essential part of the RNA processing machinery in eukaryotic cells. In particular SNRPB2 is part of the U2 small nuclear ribonucleoprotein (snRNP) complex acting in spliceosome assembly and RNA splicing events.
Biological function summary

Proteins like SNRPB2 contribute to the regulation of gene expression by ensuring the accurate removal of introns from precursor mRNA. SNRPB2 exists as part of the U2 snRNP an important component of the spliceosome. This complex participates in recognizing the splicing sites and catalyzing the chemical reactions necessary for intron excision. Therefore SNRPB2 along with other proteins and RNA molecules within the spliceosome guarantees precise RNA maturation which is necessary for correct protein synthesis in eukaryotic cells.

Pathways

RNA splicing machinery like the spliceosome featuring SNRPB2 engages in the RNA processing pathway. This protein often works alongside U1 snRNP and is also interconnected with mRNA surveillance mechanisms ensuring that errors in RNA transcripts are recognized and degraded. Importantly SNRPB2 has relationships with other spliceosome components such as SF3A and SF3B that also ensure the fidelity of the splicing process and its integration with various cellular signaling pathways.

Mutations or malfunctions in SNRPB2 have links with conditions like retinitis pigmentosa and spinal muscular atrophy. These genetic disorders often stem from disruptions in the normal splicing processes that are essential for nerve and photoreceptor cell function. In these disorders connections have been made between SNRPB2 and other related proteins such as SMN1 in spinal muscular atrophy further illustrating the complexity of its involvement in maintaining healthy cellular function and gene expression.
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Specifications

Form

Liquid

Additional notes

ab107134 is purified using conventional chromatography techniques.

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General info

Function

Involved in pre-mRNA splicing as component of the spliceosome (PubMed : 11991638, PubMed : 28076346, PubMed : 28502770, PubMed : 28781166, PubMed : 32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed : 32494006, PubMed : 9716128).

Sequence similarities

Belongs to the RRM U1 A/B'' family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Involved in pre-mRNA splicing as component of the spliceosome (PubMed : 11991638, PubMed : 28076346, PubMed : 28502770, PubMed : 28781166, PubMed : 32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed : 32494006, PubMed : 9716128).
See full target information SNRPB2
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