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AB226430

Recombinant Human SOCS1 protein (His tag)

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Recombinant Human SOCS1 protein (His tag) is a Human Full Length protein, in the 1 to 211 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

SSI1, TIP3, SOCS1, Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, JAB, SSI-1, TIP-3

3 Images
Mass Spectrometry - Recombinant Human SOCS1 protein (His tag) (AB226430)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Human SOCS1 protein (His tag) (AB226430)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS analysis result of ab226430 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SOCS1.

Mass Spectrometry - Recombinant Human SOCS1 protein (His tag) (AB226430)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Human SOCS1 protein (His tag) (AB226430)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS analysis result of ab226430 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SOCS1.

SDS-PAGE - Recombinant Human SOCS1 protein (His tag) (AB226430)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SOCS1 protein (His tag) (AB226430)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab226430 with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

O15524

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Complementary Products

Primary Antibodies

AB9870

Anti-SOCS1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS1 antibody (AB9870)

  • 5
  • 4
Proteins & Peptides

AB177638

Recombinant Human SOCS3 protein (denatured)

SDS-PAGE - Recombinant Human SOCS3 protein (denatured) (AB177638)

  • 0
  • 0
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Proteins & Peptides

AB52953

Recombinant Staphylococcus aureus Protein A

Size Exclusion Chromatography - Recombinant Staphylococcus aureus Protein A (AB52953)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI","proteinLength":"Full Length","predictedMolecularWeight":"27.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":211,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O15524","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed : 32499645, PubMed : 33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed : 9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed : 11278610, PubMed : 11313480).

Sequence similarities

Belongs to the SOCS1 family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed : 32499645, PubMed : 33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed : 9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed : 11278610, PubMed : 11313480).
See full target information SOCS1
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Product promise

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