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AB271552

Recombinant Human soluble IL2 Receptor beta protein (Avi tag C-Terminus + His tag C-Terminus)

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Recombinant Human soluble IL2 Receptor beta protein (Avi tag C-Terminus + His tag C-Terminus) is a Human Fragment protein, in the 27 to 239 aa range, expressed in HEK 293 cells, with >74%, suitable for SDS-PAGE.

View Alternative Names

CD122, IL15RB, IL2RB, Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, Interleukin-15 receptor subunit beta, p70-75, p75

1 Images
SDS-PAGE - Recombinant Human soluble IL2 Receptor beta protein (Avi tag C-Terminus + His tag C-Terminus) (AB271552)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human soluble IL2 Receptor beta protein (Avi tag C-Terminus + His tag C-Terminus) (AB271552)

SDS-PAGE analysis of 4 μg ab271552.

This protein runs at a higher MW by SDS-PAGE due to glycosylation.

Key facts

Purity

>74% SDS-PAGE

Expression system

HEK 293 cells

Tags

Avi tag C-Terminus His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P14784

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.13% Sodium phosphate, 0.02% Potassium chloride

storage-buffer

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Axl antibody [EPR19880] (AB219651)

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Primary Antibodies

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Anti-IL2 Receptor beta/p75 antibody [EPR22892-2]

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Proteins & Peptides

AB7403

Streptavidin (HRP)

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  • 5
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>This protein runs at a higher MW by SDS-PAGE due to glycosylation.</p>" } } }
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Sequence info

[{"sequence":"AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKD","proteinLength":"Fragment","predictedMolecularWeight":"28 kDa","actualMolecularWeight":null,"aminoAcidEnd":239,"aminoAcidStart":27,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P14784","tags":[{"tag":"Avi","terminus":"C-Terminus"},{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The soluble IL2 Receptor beta also known as IL2Rβ or CD122 is a component of the interleukin-2 beta receptor complex. It has a molecular mass of approximately 55 kDa. IL2Rβ exists in both membrane-bound and soluble forms. This receptor is expressed on various immune cells including natural killer cells and some T lymphocytes. The soluble form of IL2Rβ can be detected in body fluids and often increases in response to immune activation.
Biological function summary

The soluble IL2 Receptor beta plays an important role in immune system regulation by modulating the activity of its ligand the IL2 protein. It forms part of the high-affinity IL-2 receptor complex typically with IL2Rα (CD25) and IL2Rγ (CD132). This complex facilitates the response to IL-2 signaling which is essential for the proliferation and differentiation of immune cells. The receptor is also involved in the generation and maintenance of regulatory T cells important for immune tolerance.

Pathways

The soluble IL2 Receptor beta is involved in the IL-2 signaling pathway which controls T cell growth by altering gene transcription through the JAK-STAT pathway. IL2Rβ interacts with proteins like STAT5 and JAK1 which mediate signal transduction to achieve biological effects. This pathway is critical for immune responses and lymphocyte development where IL2 and similar cytokines regulate immune cell functions.

The role of soluble IL2 Receptor beta is significant in conditions like leukemia and autoimmune diseases. Elevated levels of soluble IL2Rβ often associate with hematological malignancies indicating tumor burden and disease activity in leukemia. Furthermore it has connections to proteins such as TNF-alpha in autoimmune diseases where they might contribute to inflammation and immune dysregulation highlighting its potential as a therapeutic target or biomarker.
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Specifications

Form

Liquid

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General info

Function

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed : 15123770, PubMed : 31040185).

Sequence similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

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Product protocols

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Target data

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed : 15123770, PubMed : 31040185).
See full target information IL2RB
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