Recombinant Human soluble IL2 Receptor gamma protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The soluble IL2 Receptor gamma also known as sIL-2Rγ plays an important role in the immune system. This receptor often referring to IL2RG or IL-2R gamma weighs approximately 25-30 kDa. Expression of soluble IL-2R gamma occurs mostly on the surface of various immune cells including T cells B cells and natural killer cells. The receptor exists as a component of the membrane-bound cytokine receptor complex contributing to immune signaling.

Biological function summary

The soluble IL-2 Receptor gamma engages in immune modulation processes by acting as a part of the interleukin receptor complex such as IL-2 IL-4 IL-7 IL-9 IL-15 and IL-21 receptor complexes. This engagement promotes lymphocyte proliferation and differentiation which are critical for adaptive immune response. The soluble form of the receptor may act as a modulator by binding cytokines in circulation influencing immune signaling pathways.

Pathways

The soluble IL-2 Receptor gamma plays an essential role in the JAK-STAT signaling pathway and the PI3K-Akt pathway. These pathways regulate various aspects of immune cell development and function which are important for maintaining homeostasis in the immune system. Related proteins such as JAK1 JAK3 and STAT5 associate with IL-2RG to facilitate signal transduction and elicit appropriate cellular responses through these pathways.

Soluble IL-2 Receptor gamma exhibits relevance to X-linked severe combined immunodeficiency (X-SCID) and multiple sclerosis. The receptor's genetic mutations or dysregulation can disrupt immune signaling leading to immunodeficiencies such as X-SCID where patients exhibit compromised immune defenses. In multiple sclerosis altered levels of soluble IL-2R gamma may indicate immune activation related to the disease. Connections with proteins like IL-2 and IL-15 both of which signal through IL-2RG help further understand these conditions.