Recombinant Human soluble IL2 Receptor gamma protein (Fc Chimera) is a Human Fragment protein, in the 23 to 254 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
L N T T I L T P N G N E D T T A D F F L T T M P T D S L S V S T L P L P E V Q C F V F N V E Y M N C T W N S S S E P Q P T N L T L H Y W Y K N S D N D K V Q K C S H Y L F S E E I T S G C Q L Q K K E I H L Y Q T F V V Q L Q D P R E P R R Q A T Q M L K L Q N L V I P W A P E N L T L H K L S E S Q L E L N W N N R F L N H C L E H L V Q Y R T D W D H S W T E Q S V D Y R H K F S L P S V D G Q K R Y T F R V R S R F N P L C G S A Q H W S E W S H P I H W G S N T S K E N
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Function
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770).
Alternative names
CD132, Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit gamma, gammaC, p64, IL-2 receptor subunit gamma, IL-2R subunit gamma, IL-2RG, IL2RG
Recommended products
Recombinant Human soluble IL2 Receptor gamma protein (Fc Chimera) is a Human Fragment protein, in the 23 to 254 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P31785-1
- Animal free
- No
- Species
- Human
- Reconstitution
- Reconstitute at 50 µg/mL in water
- Concentration
- Storage buffer
pH: 7.4
Constituents: 3% Trehalose, 0.75% Glycine, 0.6% Tris
Sequence info
Amino acid sequence
- L N T T I L T P N G N E D T T A D F F L T T M P T D S L S V S T L P L P E V Q C F V F N V E Y M N C T W N S S S E P Q P T N L T L H Y W Y K N S D N D K V Q K C S H Y L F S E E I T S G C Q L Q K K E I H L Y Q T F V V Q L Q D P R E P R R Q A T Q M L K L Q N L V I P W A P E N L T L H K L S E S Q L E L N W N N R F L N H C L E H L V Q Y R T D W D H S W T E Q S V D Y R H K F S L P S V D G Q K R Y T F R V R S R F N P L C G S A Q H W S E W S H P I H W G S N T S K E N
- Accession
- P31785
- Protein length
- Fragment
- Predicted molecular weight
- 53.5 kDa
- Amino acids
- 23 to 254
- Nature
- Recombinant
- Tags
- Fc tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770).
- Sequence similarities
Belongs to the type I cytokine receptor family. Type 5 subfamily.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon reconstitution add a carrier protein (0.1% BSA)
- Storage information
- Avoid freeze / thaw cycle
Notes
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The soluble IL2 Receptor gamma also known as sIL-2Rγ plays an important role in the immune system. This receptor often referring to IL2RG or IL-2R gamma weighs approximately 25-30 kDa. Expression of soluble IL-2R gamma occurs mostly on the surface of various immune cells including T cells B cells and natural killer cells. The receptor exists as a component of the membrane-bound cytokine receptor complex contributing to immune signaling.
- Biological function summary
The soluble IL-2 Receptor gamma engages in immune modulation processes by acting as a part of the interleukin receptor complex such as IL-2 IL-4 IL-7 IL-9 IL-15 and IL-21 receptor complexes. This engagement promotes lymphocyte proliferation and differentiation which are critical for adaptive immune response. The soluble form of the receptor may act as a modulator by binding cytokines in circulation influencing immune signaling pathways.
- Pathways
The soluble IL-2 Receptor gamma plays an essential role in the JAK-STAT signaling pathway and the PI3K-Akt pathway. These pathways regulate various aspects of immune cell development and function which are important for maintaining homeostasis in the immune system. Related proteins such as JAK1 JAK3 and STAT5 associate with IL-2RG to facilitate signal transduction and elicit appropriate cellular responses through these pathways.
- Associated diseases and disorders
Soluble IL-2 Receptor gamma exhibits relevance to X-linked severe combined immunodeficiency (X-SCID) and multiple sclerosis. The receptor's genetic mutations or dysregulation can disrupt immune signaling leading to immunodeficiencies such as X-SCID where patients exhibit compromised immune defenses. In multiple sclerosis altered levels of soluble IL-2R gamma may indicate immune activation related to the disease. Connections with proteins like IL-2 and IL-15 both of which signal through IL-2RG help further understand these conditions.
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1 product image
SDS-PAGE - Recombinant Human soluble IL2 Receptor gamma protein (Fc Chimera) (ab174081)
SDS-PAGE analysis of reduced ab174081 stained overnight with Coomassie Blue. The protein migrates as 95-96 kDa due to glycosylation.
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