Recombinant Human SorCS1 protein (His tag) is a Human Fragment protein, in the 111 to 1099 aa range, expressed in HEK 293, with >92% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >92% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
S G A D Q E K A E R G E G A S R S P R G V L R D G G Q Q E P G T R E R D P D K A T R F R M E E L R L T S T T F A L T G D S A H N Q A M V H W S G H N S S V I L I L T K L Y D Y N L G S I T E S S L W R S T D Y G T T Y E K L N D K V G L K T I L S Y L Y V C P T N K R K I M L L T D P E I E S S L L I S S D E G A T Y Q K Y R L N F Y I Q S L L F H P K Q E D W I L A Y S Q D Q K L Y S S A E F G R R W Q L I Q E G V V P N R F Y W S V M G S N K E P D L V H L E A R T V D G H S H Y L T C R M Q N C T E A N R N Q P F P G Y I D P D S L I V Q D H Y V F V Q L T S G G R P H Y Y V S Y R R N A F A Q M K L P K Y A L P K D M H V I S T D E N Q V F A A V Q E W N Q N D T Y N L Y I S D T R G V Y F T L A L E N V Q S S R G P E G N I M I D L Y E V A G I K G M F L A N K K I D N Q V K T F I T Y N K G R D W R L L Q A P D T D L R G D P V H C L L P Y C S L H L H L K V S E N P Y T S G I I A S K D T A P S I I V A S G N I G S E L S D T D I S M F V S S D A G N T W R Q I F E E E H S V L Y L D Q G G V L V A M K H T S L P I R H L W L S F D E G R S W S K Y S F T S I P L F V D G V L G E P G E E T L I M T V F G H F S H R S E W Q L V K V D Y K S I F D R R C A E E D Y R P W Q L H S Q G E A C I M G A K R I Y K K R K S E R K C M Q G K Y A G A M E S E P C V C T E A D F D C D Y G Y E R H S N G Q C L P A F W F N P S S L S K D C S L G Q S Y L N S T G Y R K V V S N N C T D G V R E Q Y T A K P Q K C P G K A P R G L R I V T A D G K L T A E Q G H N V T L M V Q L E E G D V Q R T L I Q V D F G D G I A V S Y V N L S S M E D G I K H V Y Q N V G I F R V T V Q V D N S L G S D S A V L Y L H V T C P L E H V H L S L P F V T T K N K E V N A T A V L W P S Q V G T L T Y V W W Y G N N T E P L I T L E G S I S F R F T S E G M N T I T V Q V S A G N A I L Q D T K T I A V Y E E F R S L R L S F S P N L D D Y N P D I P E W R R D I G R V I K K S L V E A T G V P G Q H I L V A V L P G L P T T A E L F V L P Y Q D P A G E N K R S T D D L E Q I S E L L I H T L N Q N S V H F E L K P G V R V L V H A A H L T A A P L V D L T P T H S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
SORCS, SORCS1, VPS10 domain-containing receptor SorCS1, hSorCS
Recommended products
Recombinant Human SorCS1 protein (His tag) is a Human Fragment protein, in the 111 to 1099 aa range, expressed in HEK 293, with >92% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >92% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q8WY21-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- S G A D Q E K A E R G E G A S R S P R G V L R D G G Q Q E P G T R E R D P D K A T R F R M E E L R L T S T T F A L T G D S A H N Q A M V H W S G H N S S V I L I L T K L Y D Y N L G S I T E S S L W R S T D Y G T T Y E K L N D K V G L K T I L S Y L Y V C P T N K R K I M L L T D P E I E S S L L I S S D E G A T Y Q K Y R L N F Y I Q S L L F H P K Q E D W I L A Y S Q D Q K L Y S S A E F G R R W Q L I Q E G V V P N R F Y W S V M G S N K E P D L V H L E A R T V D G H S H Y L T C R M Q N C T E A N R N Q P F P G Y I D P D S L I V Q D H Y V F V Q L T S G G R P H Y Y V S Y R R N A F A Q M K L P K Y A L P K D M H V I S T D E N Q V F A A V Q E W N Q N D T Y N L Y I S D T R G V Y F T L A L E N V Q S S R G P E G N I M I D L Y E V A G I K G M F L A N K K I D N Q V K T F I T Y N K G R D W R L L Q A P D T D L R G D P V H C L L P Y C S L H L H L K V S E N P Y T S G I I A S K D T A P S I I V A S G N I G S E L S D T D I S M F V S S D A G N T W R Q I F E E E H S V L Y L D Q G G V L V A M K H T S L P I R H L W L S F D E G R S W S K Y S F T S I P L F V D G V L G E P G E E T L I M T V F G H F S H R S E W Q L V K V D Y K S I F D R R C A E E D Y R P W Q L H S Q G E A C I M G A K R I Y K K R K S E R K C M Q G K Y A G A M E S E P C V C T E A D F D C D Y G Y E R H S N G Q C L P A F W F N P S S L S K D C S L G Q S Y L N S T G Y R K V V S N N C T D G V R E Q Y T A K P Q K C P G K A P R G L R I V T A D G K L T A E Q G H N V T L M V Q L E E G D V Q R T L I Q V D F G D G I A V S Y V N L S S M E D G I K H V Y Q N V G I F R V T V Q V D N S L G S D S A V L Y L H V T C P L E H V H L S L P F V T T K N K E V N A T A V L W P S Q V G T L T Y V W W Y G N N T E P L I T L E G S I S F R F T S E G M N T I T V Q V S A G N A I L Q D T K T I A V Y E E F R S L R L S F S P N L D D Y N P D I P E W R R D I G R V I K K S L V E A T G V P G Q H I L V A V L P G L P T T A E L F V L P Y Q D P A G E N K R S T D D L E Q I S E L L I H T L N Q N S V H F E L K P G V R V L V H A A H L T A A P L V D L T P T H S
- Accession
- Q8WY21
- Protein length
- Fragment
- Predicted molecular weight
- 113 kDa
- Amino acids
- 111 to 1099
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Sequence similarities
Belongs to the VPS10-related sortilin family. SORCS subfamily.
- Post-translational modifications
O-glycosylated.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SorCS1 also known as Sortilin-related Vps10 domain containing receptor 1 is a multifunctional protein with a mass of approximately 130 kDa. The protein primarily operates as a sorting receptor within cells influencing protein trafficking. It can bind neurotrophins regulate their transport and manage degradation pathways. SorCS1 is expressed in various tissues including the central nervous system muscle and pancreas. Notably it functions on the cell surface but is also present in distinct intracellular compartments.
- Biological function summary
This protein impacts neuronal development and glucose metabolism. SorCS1 belongs to the Vps10p domain receptor family which partakes in protein sorting processes. It is involved in amyloid-beta metabolism and modulates insulin receptor signaling. Through these interactions SorCS1 indirectly affects energy balance and brain function making it significant for neural cell maintenance and metabolic regulation.
- Pathways
SorCS1 interacts with cellular mechanisms like insulin signaling and amyloid-beta processing. It modulates the insulin signaling pathway by interacting with the insulin receptor. SorCS1 also influences the amyloid precursor protein (APP) processing pathway impacting the production of amyloid-beta. These pathways link SorCS1 functionally to proteins like sortilin and low-density lipoprotein receptor-related protein 1 (LRP1) highlighting its role in intersecting signaling mechanisms.
- Associated diseases and disorders
Research indicates SorCS1's connection to diabetes and Alzheimer's disease. It can influence the development of type 2 diabetes by modulating insulin signaling pathways and impacting glucose homeostasis. SorCS1 affects the accumulation of amyloid-beta peptides an important factor in Alzheimer's disease progression. SorCS1’s relationships with proteins such as APP and LRP1 deepen its relevance to these conditions presenting it as a potential therapeutic target for intervention.
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SDS-PAGE - Recombinant Human SorCS1 protein (His tag) (ab276446)
SDS-PAGE analysis of ab276446
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