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AB276446

Recombinant Human SorCS1 protein (His tag)

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Recombinant Human SorCS1 protein (His tag) is a Human Fragment protein, in the 111 to 1099 aa range, expressed in HEK 293 cells, with >92%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

SORCS, SORCS1, VPS10 domain-containing receptor SorCS1, hSorCS

1 Images
SDS-PAGE - Recombinant Human SorCS1 protein (His tag) (AB276446)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SorCS1 protein (His tag) (AB276446)

SDS-PAGE analysis of ab276446

Key facts

Purity

>92% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8WY21

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"SGADQEKAERGEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEPCVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGIAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAGNAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHILVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVLVHAAHLTAAPLVDLTPTHS","proteinLength":"Fragment","predictedMolecularWeight":"113 kDa","actualMolecularWeight":null,"aminoAcidEnd":1099,"aminoAcidStart":111,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8WY21","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SorCS1 also known as Sortilin-related Vps10 domain containing receptor 1 is a multifunctional protein with a mass of approximately 130 kDa. The protein primarily operates as a sorting receptor within cells influencing protein trafficking. It can bind neurotrophins regulate their transport and manage degradation pathways. SorCS1 is expressed in various tissues including the central nervous system muscle and pancreas. Notably it functions on the cell surface but is also present in distinct intracellular compartments.
Biological function summary

This protein impacts neuronal development and glucose metabolism. SorCS1 belongs to the Vps10p domain receptor family which partakes in protein sorting processes. It is involved in amyloid-beta metabolism and modulates insulin receptor signaling. Through these interactions SorCS1 indirectly affects energy balance and brain function making it significant for neural cell maintenance and metabolic regulation.

Pathways

SorCS1 interacts with cellular mechanisms like insulin signaling and amyloid-beta processing. It modulates the insulin signaling pathway by interacting with the insulin receptor. SorCS1 also influences the amyloid precursor protein (APP) processing pathway impacting the production of amyloid-beta. These pathways link SorCS1 functionally to proteins like sortilin and low-density lipoprotein receptor-related protein 1 (LRP1) highlighting its role in intersecting signaling mechanisms.

Research indicates SorCS1's connection to diabetes and Alzheimer's disease. It can influence the development of type 2 diabetes by modulating insulin signaling pathways and impacting glucose homeostasis. SorCS1 affects the accumulation of amyloid-beta peptides an important factor in Alzheimer's disease progression. SorCS1’s relationships with proteins such as APP and LRP1 deepen its relevance to these conditions presenting it as a potential therapeutic target for intervention.
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Specifications

Form

Lyophilized

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General info

Sequence similarities

Belongs to the VPS10-related sortilin family. SORCS subfamily.

Post-translational modifications

O-glycosylated.

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Product protocols

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Target data

See full target information SORCS1
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Complementary Products

Primary Antibodies

AB237618

Anti-SorCS1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SorCS1 antibody (AB237618)

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