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AB101051

Recombinant Human Spermidine synthase protein

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Recombinant Human Spermidine synthase protein is a Human Full Length protein, in the 1 to 302 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

SPS1, SRML1, SRM, Spermidine synthase, SPDSY, Putrescine aminopropyltransferase

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SDS-PAGE - Recombinant Human Spermidine synthase protein (AB101051)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Spermidine synthase protein (AB101051)

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P19623

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS","proteinLength":"Full Length","predictedMolecularWeight":"36 kDa","actualMolecularWeight":null,"aminoAcidEnd":302,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P19623","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Spermidine synthase also known as SPDSY or SRM catalyzes the production of spermidine from putrescine. This enzymatic reaction involves decarboxylated S-adenosylmethionine and is an essential step in polyamine synthesis. Spermidine synthase is a well-characterized enzyme with a molecular mass of approximately 35 kDa. The enzyme is predominantly expressed in tissues with high cellular turnover and proliferation such as the liver kidney and testis.
Biological function summary

Spermidine synthase plays a critical role in the synthesis of polyamines such as spermine which are vital for cell growth and differentiation. Polyamines stabilize DNA structure modulate ion channels and aid in gene expression. Spermidine synthase operates as a standalone enzyme and is not part of a multi-protein complex. Its expression levels and activity are tightly regulated reflecting its importance in cellular homeostasis and response to stress.

Pathways

Spermidine synthase is central to the polyamine biosynthesis pathway which is important for cellular proliferation. In this pathway it acts after ornithine decarboxylase converting putrescine to spermidine and before spermine synthase which produces spermine from spermidine. Spermidine synthase is also involved in the regulation of eukaryotic translation initiation highlighting its influence on protein biosynthesis and cell growth.

Aberrant expression or activity of spermidine synthase has been linked to cancer and neurodegenerative diseases. In cancer elevated levels of polyamines can promote tumor growth and survival. The enzyme's activity can be influenced by proteins such as antizyme which regulates polyamine levels. In neurodegenerative disorders like Alzheimer's disease disrupted polyamine metabolism may contribute to neuronal dysfunction. Understanding spermidine synthase's role in these conditions helps elucidate the molecular mechanisms underlying disease pathogenesis.
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Specifications

Form

Liquid

Additional notes

ab101051 is purified using conventional chromatography techniques.

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General info

Function

Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.

Sequence similarities

Belongs to the spermidine/spermine synthase family.

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Product protocols

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Target data

Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.
See full target information SRM
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Primary Antibodies

AB241496

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