Recombinant Human SPG21/Maspardin protein (His tag N-Terminus)
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(1 Publication)
Recombinant Human SPG21/Maspardin protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 308 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.
View Alternative Names
ACP33, BM-019, GL010, SPG21, Maspardin, Acid cluster protein 33, Spastic paraplegia 21 autosomal recessive Mast syndrome protein, Spastic paraplegia 21 protein
- WB
Unknown
Western blot - Recombinant Human SPG21/Maspardin protein (His tag N-Terminus) (AB86438)
15% SDS-PAGE showing ab86438 at approximately 37.1kDa (3μg).
All lanes:
Western blot - Anti-TAGLN/Transgelin antibody (<a href='/en-us/products/primary-antibodies/tagln-transgelin-antibody-ab14106'>ab14106</a>) at 1 µg/mL
Lane 1:
Western blot - Recombinant Human TAGLN/Transgelin protein (His tag N-Terminus) (<a href='/en-us/products/proteins-peptides/recombinant-human-tagln-transgelin-protein-ab101469'>ab101469</a>) at 0.01 µg
Lane 1:
Western blot - Recombinant Human SPG21/Maspardin protein (His tag N-Terminus) (ab86438)
Secondary
All lanes:
Western blot - Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-preadsorbed-ab97080'>ab97080</a>) at 1/5000 dilution
Predicted band size: 23 kDa,35 kDa
true
Exposure time: 30s
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SPG21 plays a role in cellular processes such as membrane trafficking and lysosomal function. It is a part of the protein complex involved in sorting and degrading membrane-bound proteins and lipids. Through its interactions with other proteins SPG21 helps maintain cellular homeostasis and protects cells from stress-related damage. It is sometimes associated with lysosome function regulation which is fundamental to cellular waste management.
Pathways
SPG21 interacts with molecules in the lysosomal and Golgi-related pathways. It fits into these pathways by assisting in the transport and breakdown of lysosomal enzymes. These processes are essential for cellular waste processing and lipid metabolism. SPG21 takes part in pathways with proteins like CLN3 and members of the Golgi complex sustaining cellular metabolic balance and facilitating protein recycling.
Specifications
Form
Liquid
Additional notes
ab86438 is purified using conventional chromatography techniques.
General info
Function
May play a role as a negative regulatory factor in CD4-dependent T-cell activation.
Sequence similarities
Belongs to the AB hydrolase superfamily.
Subcellular localisation
Endosome membrane
Target data
Publications (1)
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Journal of nanobiotechnology 21:305 PubMed37644565
2023
Applications
Unspecified application
Species
Unspecified reactive species
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Product promise
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