Recombinant Human SPOCK3 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SPOCK3 also known as Testican-3 is part of the SPARC family of proteins. Testican-3 has a molecular mass of approximately 50 kDa. This protein is primarily expressed in the central nervous system particularly in the brain and is also found in cartilage. It contains calcium-binding domains which suggest its involvement in cellular interactions and signaling processes. Testican-3 is mainly located in the extracellular matrix where it interacts with other matrix proteins and modulates their functions.

Biological function summary

Testican-3 plays a role in processes involving the structural integrity and remodeling of tissues. It belongs to the testican family which contributes to the regulation of matrix metalloproteinases (MMPs) and other proteins that participate in the degradation of the extracellular matrix. Testican-3's interactions help in maintaining matrix homeostasis by controlling protease activity which is critical for maintaining tissue structure and function.

Pathways

Testican-3's interactions influence the cell-extracellular matrix communication and signaling pathways. These pathways include the regulation of matrix metalloproteinases which are important for tissue remodeling and repair. Testican-3 is involved with proteins such as MMPs and other extracellular matrix components helping coordinate protease activity and influencing cellular behavior in response to environmental changes.

Testican-3's expression and regulation are linked to cancer and neurological disorders. Its influence on matrix metalloproteinases associates it with cancer by affecting tumor growth and metastasis due to its role in the matrix degradation pathway. In neurological contexts abnormalities in Testican-3 activity could impact processes such as synaptogenesis or neuroinflammation connecting it to conditions where matrix changes are relevant.