Recombinant Human SPOCK3 protein is a Human Fragment protein, in the 132 to 230 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
R G P I L S T C K Q C P V V Y P S P V C G S D G H T Y S F Q C K L E Y Q A C V L G K Q I S V K C E G H C P C P S D K P T S T S R N V K R A C S D L E F R E V A N R L R D W F K A L H E S G S Q N K K T
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.
Alternative names
TICN3, UNQ409/PRO771, SPOCK3, Testican-3
Recommended products
Recombinant Human SPOCK3 protein is a Human Fragment protein, in the 132 to 230 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9BQ16-3
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- R G P I L S T C K Q C P V V Y P S P V C G S D G H T Y S F Q C K L E Y Q A C V L G K Q I S V K C E G H C P C P S D K P T S T S R N V K R A C S D L E F R E V A N R L R D W F K A L H E S G S Q N K K T
- Accession
- Q9BQ16
- Protein length
- Fragment
- Amino acids
- 132 to 230
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.
- Post-translational modifications
Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SPOCK3 also known as Testican-3 is part of the SPARC family of proteins. Testican-3 has a molecular mass of approximately 50 kDa. This protein is primarily expressed in the central nervous system particularly in the brain and is also found in cartilage. It contains calcium-binding domains which suggest its involvement in cellular interactions and signaling processes. Testican-3 is mainly located in the extracellular matrix where it interacts with other matrix proteins and modulates their functions.
- Biological function summary
Testican-3 plays a role in processes involving the structural integrity and remodeling of tissues. It belongs to the testican family which contributes to the regulation of matrix metalloproteinases (MMPs) and other proteins that participate in the degradation of the extracellular matrix. Testican-3's interactions help in maintaining matrix homeostasis by controlling protease activity which is critical for maintaining tissue structure and function.
- Pathways
Testican-3's interactions influence the cell-extracellular matrix communication and signaling pathways. These pathways include the regulation of matrix metalloproteinases which are important for tissue remodeling and repair. Testican-3 is involved with proteins such as MMPs and other extracellular matrix components helping coordinate protease activity and influencing cellular behavior in response to environmental changes.
- Associated diseases and disorders
Testican-3's expression and regulation are linked to cancer and neurological disorders. Its influence on matrix metalloproteinases associates it with cancer by affecting tumor growth and metastasis due to its role in the matrix degradation pathway. In neurological contexts abnormalities in Testican-3 activity could impact processes such as synaptogenesis or neuroinflammation connecting it to conditions where matrix changes are relevant.
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1 product image
SDS-PAGE - Recombinant Human SPOCK3 protein (ab162373)
ab162373 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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