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AB153530

Recombinant Human SPP protein (GST tag N-Terminus)

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Recombinant Human SPP protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 143 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

H13, IMP1, PSL3, SPP, MSTP086, HM13, Signal peptide peptidase, Intramembrane protease 1, Minor histocompatibility antigen H13, Presenilin-like protein 3, Signal peptide peptidase-like 1, IMP-1, IMPAS-1, hIMP1

1 Images
SDS-PAGE - Recombinant Human SPP protein (GST tag N-Terminus) (AB153530)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SPP protein (GST tag N-Terminus) (AB153530)

ab153530 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q8TCT9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Signal Peptide Peptidase.
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Sequence info

[{"sequence":"MDSALSDPHNGSAEAGGPTNSTTRPPSTPEGIALAYGSLLLMALLPIFFGALRSVRCARGKNASDMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYINLLLSMYFFVLGILALSHTIRSEGISLQHLKQLSREPVQGLG","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":143,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8TCT9","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Catalyzes intramembrane proteolysis of signal peptides that have been removed from precursors of secretory and membrane proteins, resulting in the release of the fragment from the ER membrane into the cytoplasm (PubMed : 12077416). Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed : 11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed : 12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed : 11714810, PubMed : 12077416, PubMed : 14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed : 25239945). May play a role in graft rejection (By similarity).

Sequence similarities

Belongs to the peptidase A22B family.

Post-translational modifications

N-glycosylated.

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Product protocols

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Target data

Catalyzes intramembrane proteolysis of signal peptides that have been removed from precursors of secretory and membrane proteins, resulting in the release of the fragment from the ER membrane into the cytoplasm (PubMed : 12077416). Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed : 11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed : 12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed : 11714810, PubMed : 12077416, PubMed : 14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed : 25239945). May play a role in graft rejection (By similarity).
See full target information HM13
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Product promise

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