Recombinant Human sRANKL protein
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Recombinant Human sRANKL protein is a Human Full Length protein, in the 140 to 317 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
CD254, OPGL, RANKL, TRANCE, TNFSF11, Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, ODF
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human sRANKL protein (AB108129)
15% SDS-PAGE analysis of 3µg ab108129.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SRANKL facilitates the differentiation and activation of osteoclasts which are cells responsible for bone resorption. It binds to its receptor RANK on osteoclast precursors promoting their maturation into fully functional osteoclasts. This binding process involves complex formation and interaction with another molecule called osteoprotegerin (OPG) which acts as a decoy receptor regulating sRANKL activity and therefore controlling bone resorption.
Pathways
SRANKL plays a fundamental role in the RANK/RANKL/OPG signaling pathway which is important for maintaining bone homeostasis. This pathway regulates the balance between bone formation and resorption. It also interacts with NF-kappaB signaling a pathway that influences inflammation and immune response. sRANKL through these pathways closely connects with proteins such as TRAF6 which mediates downstream signaling leading to osteoclastogenesis.
Specifications
Form
Liquid
Additional notes
ab108129 was purified using conventional chromatography.
General info
Function
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed : 22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).
Sequence similarities
Belongs to the tumor necrosis factor family.
Post-translational modifications
The soluble form of isoform 1 derives from the membrane form by proteolytic processing (By similarity). The cleavage may be catalyzed by ADAM17.
Target data
Complementary Products
Primary Antibodies
AB281022
Anti-RANKL antibody [EPR24036-179] - BSA and Azide free (Detector)
RabMAb|Recombinant
![Sandwich ELISA - Anti-RANKL antibody [EPR24036-179] - BSA and Azide free (Detector) (AB281022)](https://content.abcam.com/products/images/rankl-antibody-epr24036-179-bsa-and-azide-free-detector-ab281022--sandwich-elisa-img427677.jpg)
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Product promise
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