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AB276718

Recombinant Human sRANKR protein (His tag)

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Recombinant Human sRANKR protein (His tag) is a Human Fragment protein, in the 1 to 212 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

CD265, RANK, TNFRSF11A, Tumor necrosis factor receptor superfamily member 11A, Osteoclast differentiation factor receptor, Receptor activator of NF-KB, ODFR

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SDS-PAGE - Recombinant Human sRANKR protein (His tag) (AB276718)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human sRANKR protein (His tag) (AB276718)

SDS-PAGE analysis of ab276718

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9Y6Q6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVCSSSLPARKPPNEPHVYLP","proteinLength":"Fragment","predictedMolecularWeight":"21.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":212,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9Y6Q6","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SRANKR also known as soluble receptor activator of nuclear factor kappa B receptor is a protein involved in important signaling within cells. It is expressed mainly in bone tissue and immune cells. sRANKR consists of approximately 38 kDa mass. It acts by binding the ligands that usually interact with the RANK receptor which is found on the cell surface modulating the effects of these interactions by acting as a decoy receptor.
Biological function summary

SRANKR plays a role in regulating bone metabolism and immune function. It serves as a part of a complex with RANKL (RANK Ligand) and OPG (Osteoprotegerin) mediating critical interactions within this system. sRANKR acts by inhibiting the binding of RANKL to RANK thereby influencing the process of bone resorption and immune cell activation. This modulation suggests it has a negative regulatory role in these biological processes.

Pathways

SRANKR's function integrates tightly within the RANK/RANKL/OPG signaling pathway which is important for the regulation of bone remodeling and immune response. The RANK/RANKL/OPG axis involves intricate interactions with RANKL binding to RANK to promote osteoclast differentiation while sRANKR and OPG inhibit this interaction. These pathways highlight a balance necessary for maintaining bone homeostasis and immune cell functions in normal physiological conditions.

SRANKR is relevant in osteoporosis and rheumatoid arthritis. Its role in intercepting the RANKL and RANK interaction involves the regulation of bone density by preventing excessive osteoclast activity which can lead to bone degradation in osteoporosis. In rheumatoid arthritis sRANKR modulates immune responses and inflammation through its interaction with proteins like RANK and RANKL contributing to the pathological bone erosion observed in this autoimmune condition.
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Specifications

Form

Lyophilized

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General info

Function

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed : 9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity).

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Product protocols

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Target data

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed : 9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity).
See full target information TNFRSF11A
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