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AB161147

Recombinant Human SRSF10 protein (GST tag N-Terminus)

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(1 Publication)

Recombinant Human SRSF10 protein (GST tag N-Terminus) is a Human Fragment protein, in the 1 to 100 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

FUSIP1, FUSIP2, SFRS13A, TASR, SRSF10, Serine/arginine-rich splicing factor 10, 40 kDa SR-repressor protein, FUS-interacting serine-arginine-rich protein 1, Splicing factor SRp38, TLS-associated protein with Ser-Arg repeats, TLS-associated serine-arginine protein, SRrp40, TLS-associated protein with SR repeats, TLS-associated SR protein

1 Images
SDS-PAGE - Recombinant Human SRSF10 protein (GST tag N-Terminus) (AB161147)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SRSF10 protein (GST tag N-Terminus) (AB161147)

ab161147 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

O75494

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Primary Antibodies

AB254935

Anti-SRSF10 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SRSF10 antibody (AB254935)

  • 0
  • 0
Primary Antibodies

AB272582

Anti-TRIM35 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIM35 antibody (AB272582)

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Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as FUSIP1.
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Sequence info

[{"sequence":"MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKE","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":100,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O75494","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed : 11684676, PubMed : 12419250, PubMed : 14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed : 14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed : 14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed : 26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed : 26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed : 12419250).

Sequence similarities

Belongs to the splicing factor SR family.

Post-translational modifications

Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock.

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Product protocols

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Target data

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed : 11684676, PubMed : 12419250, PubMed : 14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed : 14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed : 14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed : 26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed : 26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed : 12419250).
See full target information SRSF10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of gastrointestinal oncology 13:1927-1941 PubMed36092356

2022

A novel biomarker NIFK-AS1 promotes hepatocellular carcinoma cell cycle progression through interaction with .

Applications

Unspecified application

Species

Unspecified reactive species

Huibin Song,Wenjing Li,Sixuan Guo,Zhentao He,Shi Liu,Yongsheng Duo
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Product promise

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