Recombinant Human SSR2 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SSR2 also known as TRAP beta is a subunit of the signal sequence receptor complex with a mass around 39 kDa. It plays an important mechanical role in the translocation of proteins across the endoplasmic reticulum (ER) membrane. SSR2 is highly expressed in the ER and is mainly found in cells with active protein synthesis. The protein serves as a part of a receptor complex that aids in the proper insertion and orientation of signal peptide-bearing proteins during ER-membrane translocation.

Biological function summary

The signal sequence receptor complex including SSR2 ensures the efficient synthesis and targeting of secretory and membrane proteins to the ER. This complex consists of SSR1 SSR2 SSR3 and SSR4 and is integral to keeping the translation machinery engaged with the ER membrane. By mediating the correct insertion of nascent peptide chains it helps maintain proper function and balance within the cell’s protein sorting and post-translational processes.

Pathways

The signal sequence receptor complex which includes SSR2 is key in the protein targeting and translocation pathway. This pathway important for ER-targeted protein synthesis ensures proteins are correctly localized within cellular compartments. SSR2 interacts with other proteins such as Sec61 playing an important role in coordinating with the translocon complex and maintaining productive interactions that guide polypeptides into the ER.

SSR2 has links to certain conditions related to protein misfolding and transport deficiencies. Misregulated or dysfunctional SSR2 can contribute to disorders such as cystic fibrosis and some forms of congenital disorders of glycosylation. It shares mechanistic roles with proteins like calnexin which also help in ER function and protein folding meaning issues in SSR2 or related pathways can potentially lead to diseases arising from improper protein folding or ER stress.