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Recombinant Human SSSCA1 protein (denatured) is a Human Full Length protein, in the 1 to 199 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.

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Images

SDS-PAGE - Recombinant Human SSSCA1 protein (denatured) (AB174559), expandable thumbnail

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

Biologically active

No

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S M A L N G A E V D D F S W E P P T E A E T K V L Q A R R E R Q D R I S R L M G D Y L L R G Y R M L G E T C A D C G T I L L Q D K Q R K I Y C V A C Q E L D S D V D K D N P A L N A Q A A L S Q A R E H Q L A S A S E L P L G S R P A P Q P P V P R P E H C E G A A A G L K A A Q G P P A P A V P P N T D V M A C T Q T A L L Q K L T W A S A E L G S S T S L E T S I Q L C G L I R A C A E A L R S L Q Q L Q H

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

Alternative names

Recommended products

Recombinant Human SSSCA1 protein (denatured) is a Human Full Length protein, in the 1 to 199 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE

Accession
O60232-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

Sequence info

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S M A L N G A E V D D F S W E P P T E A E T K V L Q A R R E R Q D R I S R L M G D Y L L R G Y R M L G E T C A D C G T I L L Q D K Q R K I Y C V A C Q E L D S D V D K D N P A L N A Q A A L S Q A R E H Q L A S A S E L P L G S R P A P Q P P V P R P E H C E G A A A G L K A A Q G P P A P A V P P N T D V M A C T Q T A L L Q K L T W A S A E L G S S T S L E T S I Q L C G L I R A C A E A L R S L Q Q L Q H

Accession

O60232

Protein length

Full Length

Predicted molecular weight

23.9 kDa

Amino acids

1 to 199

Nature

Recombinant

Tags

His tag N-Terminus

Specifications

Form

Liquid

General info

Function

Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SSSCA1 also known as spindle and kinetochore-associated complex subunit 1 is a protein with a molecular mass of approximately 11 kDa. It plays a significant role in cell division. SSSCA1 localizes to the nucleus and associates with the mitotic spindle during cell cycle progression. Expression of SSSCA1 can vary across different tissues but it is particularly prominent in rapidly dividing cells including those in the testis and thymus.

Biological function summary

The protein acts as a critical player in the regulation of mitosis. SSSCA1 forms part of a larger multiprotein complex essential for the proper attachment of chromosomes to the mitotic spindle. By ensuring that the chromosomes align correctly SSSCA1 facilitates accurate segregation during cell division. It works closely with other components of the complex to maintain genomic stability.

Pathways

The protein influences critical cell division processes. SSSCA1 integrates into the spindle assembly checkpoint pathway ensuring the proper timing of mitosis. Within this pathway it often interacts with proteins such as BubR1 and Mad2 which are responsible for halting cell cycle progression until chromosomes are correctly attached to the spindle fibers. Its role in checkpoint pathways highlights its importance in maintaining orderly mitotic progression.

Associated diseases and disorders

Defects in the expression or function of SSSCA1 have connections to cancer development. Cancer cells frequently exhibit abnormal cell division and dysregulation of SSSCA1 can exacerbate these issues. The protein's interaction with p53 a well-known tumor suppressor protein might further hint at its relevance to cancer proliferation. Additionally anomalies in the functioning of SSSCA1 have also been observed in various chromosomal instability syndromes highlighting its influence in maintaining chromosome integrity.

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1 product image

  • SDS-PAGE - Recombinant Human SSSCA1 protein (denatured) (ab174559), expandable thumbnail

    SDS-PAGE - Recombinant Human SSSCA1 protein (denatured) (ab174559)

    15% SDS-PAGE analysis of ab174559 (3 μg)

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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