Recombinant Human SSSCA1 protein (denatured) is a Human Full Length protein, in the 1 to 199 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE
No
M G S S H H H H H H S S G L V P R G S H M G S M A L N G A E V D D F S W E P P T E A E T K V L Q A R R E R Q D R I S R L M G D Y L L R G Y R M L G E T C A D C G T I L L Q D K Q R K I Y C V A C Q E L D S D V D K D N P A L N A Q A A L S Q A R E H Q L A S A S E L P L G S R P A P Q P P V P R P E H C E G A A A G L K A A Q G P P A P A V P P N T D V M A C T Q T A L L Q K L T W A S A E L G S S T S L E T S I Q L C G L I R A C A E A L R S L Q Q L Q H
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.
SSSCA1, ZNRD2, Protein ZNRD2, Autoantigen p27, Protein zinc ribbon domain type 2, Sjoegren syndrome/scleroderma autoantigen 1, Zinc ribbon domain-containing protein 2
Recombinant Human SSSCA1 protein (denatured) is a Human Full Length protein, in the 1 to 199 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE
No
No
Human
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
M G S S H H H H H H S S G L V P R G S H M G S M A L N G A E V D D F S W E P P T E A E T K V L Q A R R E R Q D R I S R L M G D Y L L R G Y R M L G E T C A D C G T I L L Q D K Q R K I Y C V A C Q E L D S D V D K D N P A L N A Q A A L S Q A R E H Q L A S A S E L P L G S R P A P Q P P V P R P E H C E G A A A G L K A A Q G P P A P A V P P N T D V M A C T Q T A L L Q K L T W A S A E L G S S T S L E T S I Q L C G L I R A C A E A L R S L Q Q L Q H
Full Length
23.9 kDa
1 to 199
Recombinant
His tag N-Terminus
Liquid
Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
SSSCA1 also known as spindle and kinetochore-associated complex subunit 1 is a protein with a molecular mass of approximately 11 kDa. It plays a significant role in cell division. SSSCA1 localizes to the nucleus and associates with the mitotic spindle during cell cycle progression. Expression of SSSCA1 can vary across different tissues but it is particularly prominent in rapidly dividing cells including those in the testis and thymus.
The protein acts as a critical player in the regulation of mitosis. SSSCA1 forms part of a larger multiprotein complex essential for the proper attachment of chromosomes to the mitotic spindle. By ensuring that the chromosomes align correctly SSSCA1 facilitates accurate segregation during cell division. It works closely with other components of the complex to maintain genomic stability.
The protein influences critical cell division processes. SSSCA1 integrates into the spindle assembly checkpoint pathway ensuring the proper timing of mitosis. Within this pathway it often interacts with proteins such as BubR1 and Mad2 which are responsible for halting cell cycle progression until chromosomes are correctly attached to the spindle fibers. Its role in checkpoint pathways highlights its importance in maintaining orderly mitotic progression.
Defects in the expression or function of SSSCA1 have connections to cancer development. Cancer cells frequently exhibit abnormal cell division and dysregulation of SSSCA1 can exacerbate these issues. The protein's interaction with p53 a well-known tumor suppressor protein might further hint at its relevance to cancer proliferation. Additionally anomalies in the functioning of SSSCA1 have also been observed in various chromosomal instability syndromes highlighting its influence in maintaining chromosome integrity.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
15% SDS-PAGE analysis of ab174559 (3 μg)
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com