Recombinant Human SSSCA1 protein (denatured)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SSSCA1 also known as spindle and kinetochore-associated complex subunit 1 is a protein with a molecular mass of approximately 11 kDa. It plays a significant role in cell division. SSSCA1 localizes to the nucleus and associates with the mitotic spindle during cell cycle progression. Expression of SSSCA1 can vary across different tissues but it is particularly prominent in rapidly dividing cells including those in the testis and thymus.

Biological function summary

The protein acts as a critical player in the regulation of mitosis. SSSCA1 forms part of a larger multiprotein complex essential for the proper attachment of chromosomes to the mitotic spindle. By ensuring that the chromosomes align correctly SSSCA1 facilitates accurate segregation during cell division. It works closely with other components of the complex to maintain genomic stability.

Pathways

The protein influences critical cell division processes. SSSCA1 integrates into the spindle assembly checkpoint pathway ensuring the proper timing of mitosis. Within this pathway it often interacts with proteins such as BubR1 and Mad2 which are responsible for halting cell cycle progression until chromosomes are correctly attached to the spindle fibers. Its role in checkpoint pathways highlights its importance in maintaining orderly mitotic progression.

Defects in the expression or function of SSSCA1 have connections to cancer development. Cancer cells frequently exhibit abnormal cell division and dysregulation of SSSCA1 can exacerbate these issues. The protein's interaction with p53 a well-known tumor suppressor protein might further hint at its relevance to cancer proliferation. Additionally anomalies in the functioning of SSSCA1 have also been observed in various chromosomal instability syndromes highlighting its influence in maintaining chromosome integrity.