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AB181904

Recombinant Human SSX2 protein (denatured) (His tag N-Terminus)

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Recombinant Human SSX2 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 188 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

SSX2A, SSX2B, SSX2, Protein SSX2, Cancer/testis antigen 5.2, Tumor antigen HOM-MEL-40, CT5.2

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SDS-PAGE - Recombinant Human SSX2 protein (denatured) (His tag N-Terminus) (AB181904)
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Supplier Data

SDS-PAGE - Recombinant Human SSX2 protein (denatured) (His tag N-Terminus) (AB181904)

15% SDS-PAGE analysis of 3ug ab181904 stained with Coomassie Blue.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q16385

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHRSMNGDDAFARRPTVGAQIPEKIQKAFDDIAKYFSKEEWEKMKASEKIFYVYMKRKYEAMTKLGFKATLPPFMCNKRAEDFQGNDLDNDPNRGNQVERPQMTFGRLQGISPKIMPKKPAEEGNDSEEVPEASGPQNDGKELCPPGKPTTSEKIHERSGPKRGEHAWTHRLRERKQLVIYEEISDPEEDDE","proteinLength":"Full Length","predictedMolecularWeight":"22 kDa","actualMolecularWeight":null,"aminoAcidEnd":188,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q16385","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SSX2 is a member of the synovial sarcoma X (SSX) breakpoint protein family. It performs mechanical function by acting as a transcriptional repressor. This protein also known as cancer/testis antigen 5.2 (CT5.2) has a mass of approximately 23 kDa. SSX2 expression is mostly restricted to testicular tissue in healthy adults but becomes anomalously expressed in various cancers making it a cancer/testis antigen of interest in research.
Biological function summary

SSX2 binds to other nuclear proteins suggesting it forms part of a regulatory complex affecting gene transcription. Such interactions influence cell cycle progression and other cellular processes. Given its involvement in transcriptional control SSX2 exerts significant influence over cellular proliferation and differentiation. Understanding the exact mechanisms by which SSX2 interacts with DNA and other proteins remains an area of keen scientific investigation because of its unique expression patterns.

Pathways

SSX2 impacts pathways related to transcriptional regulation and cellular growth. SSX2's involvement in the Wnt signaling pathway critical for cell proliferation illustrates its regulatory influence over cellular mechanisms. Furthermore its interaction with proteins like beta-catenin within these pathways can modulate various cellular outcomes affecting oncogenesis and tissue development.

SSX2 expression shows correlation with cancers such as melanoma and synovial sarcoma. The aberrant expression in these malignancies makes SSX2 a potential target for therapeutic interventions or a marker for diagnosis. Its link with MAGE proteins another family of cancer/testis antigens adds layers to its role in cancer biology. By better understanding SSX2's function and interactions researchers can advance therapeutic strategies to target its expression in cancerous cells.
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Specifications

Form

Liquid

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General info

Function

Could act as a modulator of transcription.

Sequence similarities

Belongs to the SSX family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Could act as a modulator of transcription.
See full target information SSX2
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