Recombinant Human SSX3 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SSX3 protein also known as Synovial Sarcoma X breakpoint 3 is a protein with a mass around 20 kDa. It belongs to the SSX (Synovial Sarcoma X) family and is expressed mainly in testis and certain cancerous tissues. SSX3 functions as a transcriptional regulator and its mechanism involves modulating gene expression possibly by acting as a transcriptional corepressor. Altered expression of SSX3 occurs in different types of tumors suggesting specific roles in cancer biology.

Biological function summary

The SSX3 protein influences several cell processes by participating in gene regulation. SSX3 does not function alone but as part of protein complexes that modulate chromatin structure and accessibility. This activity affects gene transcription. SSX3 influences cellular proliferation and differentiation making it important in the development of certain tissues. The SSX3 protein’s interaction with other transcriptional regulators emphasizes its role in finely tuning gene expression.

Pathways

SSX3 plays a role in the regulation of the Wnt signaling pathway which is critical for cell proliferation and differentiation. SSX3 potentially influences this pathway through its regulatory activities on gene expression. It shares interactions with proteins like β-catenin influencing the pathway's outcome. The SSX3 protein may also interplay with the Notch signaling pathway further modulating cellular processes that guide cell fate decisions.

Altered SSX3 expression is associated with synovial sarcoma and melanoma. In synovial sarcoma SSX3 is involved due to its location at chromosomal translocation sites which results in oncogenic fusion proteins like SS18-SSX3. This fusion protein drives tumor progression. SSX3’s interactions with proteins such as SS18 and β-catenin are pivotal in these disease contexts contributing to aberrant signaling that leads to uncontrolled cellular growth and malignancy.