Recombinant human ST2 protein (Active) is a Human Fragment protein, in the 19 to 328 aa range, expressed in Baculovirus infected insect, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
>95% SDS-PAGE
< 1 EU/µg
Baculovirus infected insect cells
His tag C-Terminus
SDS-PAGE, FuncS
Yes
K F S K Q S W G L E N E A L I V R C P R Q G K P S Y T V D W Y Y S Q T N K S I P T Q E R N R V F A S G Q L L K F L P A A V A D S G I Y T C I V R S P T F N R T G Y A N V T I Y K K Q S D C N V P D Y L M Y S T V S G S E K N S K I Y C P T I D L Y N W T A P L E W F K N C Q A L Q G S R Y R A H K S F L V I D N V M T E D A G D Y T C K F I H N E N G A N Y S V T A T R S F T V K D E Q G F S L F P V I G A P A Q N E I K E V E I G K N A N L T C S A C F G K G T Q F L A A V L W Q L N G T K I T D F G E P R I Q Q E E G Q N Q S F S N G L A C L D M V L R I A D V K E E D L L L Q Y D C L A L N L H G L R R H T V R L S R K N P I D H H S L E H H H H H H
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP (PubMed:35238669). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable) (PubMed:16286016). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity).Isoform BInhibits IL-33 signaling.
DER4, ST2, T1, IL1RL1, Interleukin-1 receptor-like 1, Protein ST2
Recombinant human ST2 protein (Active) is a Human Fragment protein, in the 19 to 328 aa range, expressed in Baculovirus infected insect, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
>95% SDS-PAGE
< 1 EU/µg
Baculovirus infected insect cells
His tag C-Terminus
SDS-PAGE, FuncS
Yes
Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 for this effect is less or equal to 10 ng/ml with IL-33.
No
Human
pH: 7.4
Constituents: PBS, 10% Glycerol (glycerin, glycerine)
K F S K Q S W G L E N E A L I V R C P R Q G K P S Y T V D W Y Y S Q T N K S I P T Q E R N R V F A S G Q L L K F L P A A V A D S G I Y T C I V R S P T F N R T G Y A N V T I Y K K Q S D C N V P D Y L M Y S T V S G S E K N S K I Y C P T I D L Y N W T A P L E W F K N C Q A L Q G S R Y R A H K S F L V I D N V M T E D A G D Y T C K F I H N E N G A N Y S V T A T R S F T V K D E Q G F S L F P V I G A P A Q N E I K E V E I G K N A N L T C S A C F G K G T Q F L A A V L W Q L N G T K I T D F G E P R I Q Q E E G Q N Q S F S N G L A C L D M V L R I A D V K E E D L L L Q Y D C L A L N L H G L R R H T V R L S R K N P I D H H S L E H H H H H H
Fragment
36 kDa
19 to 328
Recombinant
His tag C-Terminus
Liquid
Affinity purified
Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP (PubMed:35238669). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable) (PubMed:16286016). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity).
Belongs to the interleukin-1 receptor family.
Ubiquitinated at Lys-321 in a FBXL19-mediated manner; leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response (PubMed:35238669).
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
This supplementary information is collated from multiple sources and compiled automatically.
ST2 also known as IL-1RL1 or IL-1RL1 chimera protein is a member of the IL-1 receptor family. It has a molecular mass of approximately 55 kDa. This protein exists in different forms including a membrane-bound form and a soluble variant. Researchers typically find ST2 expressed in various tissues including the lungs gut and cardiovascular system. The expression level can vary significantly depending on the physiological or pathological state.
ST2 interacts with interleukin-33 (IL-33) and functions as its receptor. The binding of IL-33 to ST2 activates immune responses particularly influencing T-helper 2 (Th2) cells. ST2 forms part of a receptor complex including IL-1 receptor accessory protein IL-1RAcP necessary for signal transduction. This interaction leads to the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and mitogen-activated protein kinase (MAPK) signaling pathways facilitating inflammatory responses.
IL-33 signals through the ST2 receptor participating actively in the immune signaling pathway. This pathway plays a significant role in modulating inflammatory and immune responses. ST2 association with NF-kB broadly affects inflammatory signaling while its involvement with the MAPK pathway aids in cellular responses to cytokines and stress. The close relationship with the IL-33/ST2 axis highlights its importance in maintaining immune homeostasis and reacting to environmental stressors.
ST2 has significant associations with asthma and cardiovascular diseases. In asthma the IL-33/ST2 axis critically contributes to airway inflammation and hyperresponsiveness. Similarly in the context of cardiovascular diseases elevated levels of soluble ST2 are markers of heart failure with the ST2/IL-33 axis contributing to cardiac remodeling. ST2's connection with inflammatory processes implies it also interacts with other cytokines such as interleukin-6 (IL-6) exacerbating the disease states through shared pathways.
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15% SDS-PAGE analysis of 3 μg ab233601.
MW: 40-57 kDa (SDS-PAGE under reducing conditions).
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