JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB161069

Recombinant Human ST6GALNAC2 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human ST6GALNAC2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 374 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

SIAT7B, SIATL1, STHM, ST6GALNAC2, ST6GalNAc II, SThM, Sialyltransferase 7B, ST6GalNAcII, SIAT7-B

1 Images
SDS-PAGE - Recombinant Human ST6GALNAC2 protein (AB161069)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ST6GALNAC2 protein (AB161069)

ab161069 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9UJ37

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGLPRGSFFWLLLLLTAACSGLLFALYFSAVQRYPGPAAGARDTTSFEAFFQSKASNSWTGKGQACRHLLHLAIQRHPHFRGLFNLSIPVLLWGDLFTPALWDRLSQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFAPPRDTPPKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYFERKMKPLIFYANHDLSLEAALWRDLHKAGILQLYQR","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":374,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9UJ37","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ST6GALNAC2 also known as GalNAc α-26-sialyltransferase 2 is an enzyme involved in the sialylation process. Its molecular mass is approximately 56 kDa. The enzyme is expressed prominently in human tissues like the colon small intestine and spleen. ST6GALNAC2 catalyzes the transfer of sialic acid from CMP-NeuAc to GalNAc residues of glycoproteins and glycolipids playing a role in modifying their structures.
Biological function summary

The enzyme has a significant role in the biosynthesis of sialylated structures influencing cell-cell interactions signaling and immune modulation. ST6GALNAC2 is part of the glycosyltransferase family and it acts without forming larger complexes. Its activity affects the surface glycosylation pattern of cells influencing properties like cell adhesion and signaling pathways that are critical for cellular communication.

Pathways

Sialylation influences cellular interactions and immune responses and ST6GALNAC2's addition of sialic acid units impacts these processes. It participates in the glycosphingolipid biosynthesis pathway and influences the sialylation branch of the Nglycosylation pathway. ST6GALNAC2's activities interplay with other sialyltransferases in regulating the sialylation state of glycoproteins affecting interactions with receptors such as selectins and integrins which are important in mediating cellular adhesion and trafficking.

Altered ST6GALNAC2 activity links to colorectal cancer and inflammatory bowel diseases. In colorectal cancer modifications in glycosylation patterns influenced by ST6GALNAC2 and related enzymes like ST6GALNAC1 correlate with tumor progression and metastasis. In inflammatory bowel diseases the enzyme contributes to changes in the mucosal barrier affecting immune responses and tissue integrity. Understanding ST6GALNAC2's role offers insights into therapeutic targets in these diseases.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed : 10742600, PubMed : 29251719). Shows a preference for N-acetylgalactosamine (GalNAc) residues already modified by the addition of galactose or galactose followed by sialic acid in alpha-2,3 linkage (PubMed : 10742600).

Sequence similarities

Belongs to the glycosyltransferase 29 family.

style
left-column

Product protocols

style
left-column

Target data

Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed : 10742600, PubMed : 29251719). Shows a preference for N-acetylgalactosamine (GalNAc) residues already modified by the addition of galactose or galactose followed by sialic acid in alpha-2,3 linkage (PubMed : 10742600).
See full target information ST6GALNAC2
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB229816

Anti-ST6GalNAc I antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ST6GalNAc I antibody (AB229816)

  • 0
  • 0
Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (AB159886)

  • 0
  • 0
Proteins & Peptides

AB162402

Recombinant Human Zinc finger protein 691

SDS-PAGE - Recombinant Human Zinc finger protein 691 (AB162402)

  • 0
  • 0
Proteins & Peptides

AB161146

Recombinant Human BS69 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human BS69 protein (AB161146)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com