Recombinant Human ST8SIA1 protein (His tag)
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Recombinant Human ST8SIA1 protein (His tag) is a Human Fragment protein, in the 49 to 356 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
SIAT8, SIAT8A, ST8SIA1, Ganglioside GD3 synthase, Ganglioside GT3 synthase, Sialyltransferase 8A, Sialyltransferase St8Sia I, SIAT8-A, ST8SiaI
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human ST8SIA1 protein (His tag) (AB276673)
SDS-PAGE analysis of ab276673
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ST8SIA1 modifies glycoproteins and glycolipids through sialylation affecting cellular processes like signal transduction and cell-cell interaction. This enzyme participates in ganglioside biosynthesis producing ganglioside GD3 by sialylating ganglioside GM3. It does not appear to form part of a larger complex but impacts cellular functions significantly through its enzymatic action.
Pathways
Ganglioside biosynthesis involves ST8SIA1 as an important player where it ensures the production of diverse gangliosides important for central nervous system development and function. The enzyme interacts with other players in the sialyltransferase family such as ST3GAL5 another important enzyme in glycosphingolipid pathway. These functional interactions underline its contribution to cellular differentiation and apoptosis.
Specifications
Form
Lyophilized
General info
Function
Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphingolipds that contain one or more residues of sialic acid (PubMed : 18348864, PubMed : 22885356, PubMed : 7937974, PubMed : 8058740, PubMed : 8195250, PubMed : 8631981, PubMed : 8706663). Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3 (PubMed : 8631981). Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (PubMed : 8706663). Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells (PubMed : 22885356).
Sequence similarities
Belongs to the glycosyltransferase 29 family.
Target data
Complementary Products
Product promise
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