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AB132279

Recombinant Human STAM2 protein (GST tag N-Terminus)

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Recombinant Human STAM2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 525 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

HBP, STAM2, Signal transducing adapter molecule 2, STAM-2, Hrs-binding protein

1 Images
SDS-PAGE - Recombinant Human STAM2 protein (GST tag N-Terminus) (AB132279)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human STAM2 protein (GST tag N-Terminus) (AB132279)

12.5% SDS-PAGE analysis of ab132279 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, SDS-PAGE, WB

applications

Biologically active

No

Accession

O75886

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB92544

Anti-LRP1 antibody [EPR3724]

BOND RX™ Validated|20ul selling size|KO Validated|RabMAb|Recombinant

Western blot - Anti-LRP1 antibody [EPR3724] (AB92544)

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Primary Antibodies

AB97959

Anti-SOX2 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX2 antibody (AB97959)

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Primary Antibodies

AB126724

Anti-STIP1/STI1 antibody [EPR6605]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STIP1/STI1 antibody [EPR6605] (AB126724)

  • 5
  • 6
Primary Antibodies

AB231280

Anti-STAM2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAM2 antibody (AB231280)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALELYNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQSIHQVTVAQSYSLGPDQIGPLRSLPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNSNLQSATGTTAYTQQMGMSVDMSSYQNTTSNLPQLAGFPVTVPAHPVAQQHTNYHQQPLL","proteinLength":"Full Length","predictedMolecularWeight":"83.49 kDa","actualMolecularWeight":null,"aminoAcidEnd":525,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O75886","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STAM2 also known as STAM2b acts as a signal transducing adaptor molecule. STAM2 has a mass of approximately 69 kDa and is located in the cytoplasm. It expresses widely with notable presence in the brain and immune cells. Mechanically STAM2 contains multiple functional domains including a VHS domain and a UIM domain which participate in binding ubiquitinated proteins. These features allow STAM2 to mediate interactions in cellular processes involving intracellular signaling.
Biological function summary

STAM2 plays a role in the sorting and trafficking of proteins within the cell. It forms part of the ESCRT-0 complex which is important for sorting ubiquitinated cargo into the multivesicular body (MVB) pathway. This pathway is important for the degradation of membrane proteins in lysosomes and regulating various signaling pathways including endocytosis. The involvement of STAM2 in these processes makes it essential for maintaining cellular homeostasis and regulating signal transduction.

Pathways

STAM2 is involved in both the endocytic and lysosomal degradation pathways. Within these pathways STAM2 interacts with Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) another component of the ESCRT-0 complex to regulate the sorting of endocytic cargo. This interaction is part of a larger network connecting the endocytic pathway with other cellular processes such as ubiquitin-dependent protein degradation. STAM2's functions align it with pathways necessary for proper protein turnover and cellular signaling adjustments.

STAM2's dysregulation has a noted connection to neurodegenerative diseases such as Alzheimer's disease. Changes in protein trafficking and degradation which involve STAM2 function correlate with the buildup of abnormal protein aggregates in neurons. Additionally STAM2 has been implicated in certain cancers where its interaction with proteins such as EGFR (epidermal growth factor receptor) may influence tumor growth and metastasis. Understanding how STAM2 contributes to these conditions could offer insight into potential therapeutic targets.
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Specifications

Form

Liquid

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General info

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Sequence similarities

Belongs to the STAM family.

Post-translational modifications

Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.

Subcellular localisation

Early endosome membrane

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Product protocols

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Target data

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
See full target information STAM2
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