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AB276654

Recombinant Human Stanniocalcin 1/STC protein (His tag)

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Recombinant Human Stanniocalcin 1/STC protein (His tag) is a Human Full Length protein, in the 1 to 247 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

STC, STC1, Stanniocalcin-1, STC-1

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SDS-PAGE - Recombinant Human Stanniocalcin 1/STC protein (His tag) (AB276654)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Stanniocalcin 1/STC protein (His tag) (AB276654)

SDS-PAGE analysis of ab276654

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P52823

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MLQNSAVLLVLVISASATHEAEQNDSVSPRKSRVAAQNSAEVVRCLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANGVTSKVFLAIRRCSTFQRMIAEVQEECYSKLNVCSIAKRNPEAITEVVQLPNHFSNRYYNRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNEPQKLKVLLRNLRGEEDSPSHIKRTSHESA","proteinLength":"Full Length","predictedMolecularWeight":"27.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":247,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P52823","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Stanniocalcin 1 (STC1) is a glycoprotein hormone with a mass of about 56 kDa. Alternate names for this protein include STC and STC-1. It is expressed in various tissues such as the kidney brain and ovary. STC1 plays a significant mechanical role in the regulation of calcium and phosphate transport across cell membranes. It interacts with certain receptors on cell surfaces to modulate ion exchange contributing to the maintenance of mineral homeostasis.
Biological function summary

Stanniocalcin 1 regulates calcium and phosphate balance and performs roles in cellular metabolism and antioxidant defense. It acts independently not as part of a complex but sometimes affects cascades leading to oxidative stress responses. STC1 adjusts energy metabolism by managing reactive oxygen species thereby enhancing cell survival under stress conditions. Its signaling impacts energy balance and adaptive responses in metabolically active tissues.

Pathways

Despite its independent operation Stanniocalcin 1 is integrated into oxidative stress and inflammatory pathways. It is involved in the Akt/PKB signaling pathway which influences cell survival and stress response. STC1 intersects with other proteins like PTH (parathyroid hormone) within the calcium metabolism pathways affecting bone and renal function. Through these pathways it facilitates cellular adaptation to metabolic demands.

Researchers link Stanniocalcin 1 to osteoporosis and cancer. Its role in calcium homeostasis makes it relevant in osteoporosis where bone density and strength are compromised. In the context of cancer STC1's influence on cell survival and stress responses may contribute to tumorigenesis although its function can be protective or detrimental depending on the cellular environment. The interaction of STC1 with proteins like PTH highlights its involvement in bone-related pathologies and potential roles in cancer progression.
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Specifications

Form

Lyophilized

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General info

Function

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

Sequence similarities

Belongs to the stanniocalcin family.

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Product protocols

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Target data

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
See full target information STC1
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