Recombinant Human Stanniocalcin 1/STC protein (His tag) is a Human Full Length protein, in the 1 to 247 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M L Q N S A V L L V L V I S A S A T H E A E Q N D S V S P R K S R V A A Q N S A E V V R C L N S A L Q V G C G A F A C L E N S T C D T D G M Y D I C K S F L Y S A A K F D T Q G K A F V K E S L K C I A N G V T S K V F L A I R R C S T F Q R M I A E V Q E E C Y S K L N V C S I A K R N P E A I T E V V Q L P N H F S N R Y Y N R L V R S L L E C D E D T V S T I R D S L M E K I G P N M A S L F H I L Q T D H C A Q T H P R A D F N R R R T N E P Q K L K V L L R N L R G E E D S P S H I K R T S H E S A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
Alternative names
STC, STC1, Stanniocalcin-1, STC-1
Recommended products
Recombinant Human Stanniocalcin 1/STC protein (His tag) is a Human Full Length protein, in the 1 to 247 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P52823-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M L Q N S A V L L V L V I S A S A T H E A E Q N D S V S P R K S R V A A Q N S A E V V R C L N S A L Q V G C G A F A C L E N S T C D T D G M Y D I C K S F L Y S A A K F D T Q G K A F V K E S L K C I A N G V T S K V F L A I R R C S T F Q R M I A E V Q E E C Y S K L N V C S I A K R N P E A I T E V V Q L P N H F S N R Y Y N R L V R S L L E C D E D T V S T I R D S L M E K I G P N M A S L F H I L Q T D H C A Q T H P R A D F N R R R T N E P Q K L K V L L R N L R G E E D S P S H I K R T S H E S A
- Accession
- P52823
- Protein length
- Full Length
- Predicted molecular weight
- 27.4 kDa
- Amino acids
- 1 to 247
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
- Sequence similarities
Belongs to the stanniocalcin family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Stanniocalcin 1 (STC1) is a glycoprotein hormone with a mass of about 56 kDa. Alternate names for this protein include STC and STC-1. It is expressed in various tissues such as the kidney brain and ovary. STC1 plays a significant mechanical role in the regulation of calcium and phosphate transport across cell membranes. It interacts with certain receptors on cell surfaces to modulate ion exchange contributing to the maintenance of mineral homeostasis.
- Biological function summary
Stanniocalcin 1 regulates calcium and phosphate balance and performs roles in cellular metabolism and antioxidant defense. It acts independently not as part of a complex but sometimes affects cascades leading to oxidative stress responses. STC1 adjusts energy metabolism by managing reactive oxygen species thereby enhancing cell survival under stress conditions. Its signaling impacts energy balance and adaptive responses in metabolically active tissues.
- Pathways
Despite its independent operation Stanniocalcin 1 is integrated into oxidative stress and inflammatory pathways. It is involved in the Akt/PKB signaling pathway which influences cell survival and stress response. STC1 intersects with other proteins like PTH (parathyroid hormone) within the calcium metabolism pathways affecting bone and renal function. Through these pathways it facilitates cellular adaptation to metabolic demands.
- Associated diseases and disorders
Researchers link Stanniocalcin 1 to osteoporosis and cancer. Its role in calcium homeostasis makes it relevant in osteoporosis where bone density and strength are compromised. In the context of cancer STC1's influence on cell survival and stress responses may contribute to tumorigenesis although its function can be protective or detrimental depending on the cellular environment. The interaction of STC1 with proteins like PTH highlights its involvement in bone-related pathologies and potential roles in cancer progression.
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1 product image
SDS-PAGE - Recombinant Human Stanniocalcin 1/STC protein (His tag) (ab276654)
SDS-PAGE analysis of ab276654
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