Recombinant Human STAP-1 protein
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Recombinant Human STAP-1 protein is a Human Full Length protein, in the 1 to 295 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
BRDG1, STAP1, Signal-transducing adaptor protein 1, STAP-1, BCR downstream-signaling protein 1, Docking protein BRDG1, Stem cell adaptor protein 1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human STAP-1 protein (AB126657)
ab126657 at 3 μg analysed by SDS PAGE.
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
STAP-1 modulates the signaling pathways that govern cell growth and differentiation. It participates in forming complexes with other proteins to transduce signals from the cell surface to the nucleus. STAP-1's ability to bind phosphotyrosine residues allows it to act as a scaffold for other signaling molecules in immune responses. Its interaction with other pathway proteins suggests its role in cellular processes beyond immunity influencing various cellular outcomes.
Pathways
STAP-1 integrates into the JAK-STAT signaling pathway and the PI3K-Akt pathway. These pathways play a central role in regulating immune cell function and proliferation. STAP-1 associates with proteins such as STAT3 and PI3K linking it to important signaling cascades that control gene expression and cell survival. In the JAK-STAT pathway STAP-1's interaction with STAT proteins emphasizes its involvement in transmitting extracellular cues to the nucleus.
Specifications
Form
Liquid
Additional notes
ab126657 is purified using conventional chromatography techniques
General info
Function
In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.
Post-translational modifications
Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT (By similarity).
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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