Recombinant Human StAR protein is a Human Full Length protein, in the 64 to 285 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M E E T L Y S D Q E L A Y L Q Q G E E A M Q K A L G I L S N Q E G W K K E S Q Q D N G D K V M S K V V P D V G K V F R L E V V V D Q P M E R L Y E E L V E R M E A M G E W N P N V K E I K V L Q K I G K D T F I T H E L A A E A A G N L V G P R D F V S V R C A K R R G S T C V L A G M A T D F G N M P E Q K G V I R A E H G P T C M V L H P L A G S P S K T K L T W L L S I D L K G W L P K S I I N Q V L S Q T Q V D F A N H L R K R L E S H P A S E A R C
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
Alternative names
STARD1, STAR, StAR, START domain-containing protein 1, StARD1
Recommended products
Recombinant Human StAR protein is a Human Full Length protein, in the 64 to 285 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- P49675-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M E E T L Y S D Q E L A Y L Q Q G E E A M Q K A L G I L S N Q E G W K K E S Q Q D N G D K V M S K V V P D V G K V F R L E V V V D Q P M E R L Y E E L V E R M E A M G E W N P N V K E I K V L Q K I G K D T F I T H E L A A E A A G N L V G P R D F V S V R C A K R R G S T C V L A G M A T D F G N M P E Q K G V I R A E H G P T C M V L H P L A G S P S K T K L T W L L S I D L K G W L P K S I I N Q V L S Q T Q V D F A N H L R K R L E S H P A S E A R C
- Accession
- P49675
- Protein length
- Full Length
- Predicted molecular weight
- 27.1 kDa
- Amino acids
- 64 to 285
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab115707 was purified using conventional chromatography techniques.
General info
- Function
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
- Subcellular localisation
- Mitochondrion
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Steroidogenic Acute Regulatory protein (StAR) also known as STARD1 plays an important role in steroid hormone synthesis. It facilitates the transport of cholesterol from the outer to the inner mitochondrial membrane essential for steroid biosynthesis. StAR has a molecular mass of approximately 30 kDa. Expression of StAR occurs predominantly in steroidogenic tissues like adrenal glands ovaries and testes. The protein's efficient functioning is necessary for the maintenance of proper steroid hormone levels in the body.
- Biological function summary
The transport activity of StAR is important for the production of steroid hormones which are pivotal in numerous physiological functions. StAR does not function alone; it forms a part of a larger complex of proteins involved in mitochondrial cholesterol transfer. By enabling the conversion of cholesterol to pregnenolone a precursor to various steroid hormones StAR directly affects processes such as metabolism immune function and sexual differentiation. Abnormalities in these processes can result from disruptions in StAR's activity.
- Pathways
The involvement of StAR in cholesterol transport places it in the important steroidogenic pathway. This pathway includes interactions with other pivotal proteins such as cytochrome P450scc (CYP11A1) which further converts cholesterol into pregnenolone. Another important pathway where StAR participates is the adrenal biosynthesis pathway linking it to the production of glucocorticoids and mineralocorticoids. Disruption in these pathways due to StAR deficiency or malfunction can lead to severe biological implications.
- Associated diseases and disorders
StAR is closely associated with conditions like lipoid congenital adrenal hyperplasia (LCAH) and Addison's disease. Mutations or deficiencies in StAR can interrupt steroid hormone production which is essential for managing these conditions. Additionally proteins like CYP11A1 may show functional impairment in the presence of StAR mutations exacerbating these disorders. A deeper understanding of StAR's role in these conditions can support the development of targeted therapeutic strategies.
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1 product image
SDS-PAGE - Recombinant Human StAR protein (ab115707)
15% SDS-PAGE showing ab115707 at approximately 27.1kDa (3μg).
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