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AB176085

Recombinant Human STARD5 protein

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Recombinant Human STARD5 protein is a Human Full Length protein, in the 1 to 213 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

StAR-related lipid transfer protein 5, START domain-containing protein 5, StARD5, STARD5

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SDS-PAGE - Recombinant Human STARD5 protein (AB176085)
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Supplier Data

SDS-PAGE - Recombinant Human STARD5 protein (AB176085)

3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9NSY2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris-HCl buffer, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMDPALAAQMSEAVAEKMLQYRRDTAGWKICREGNGVSVSWRPSVEFPGNLYRGEGIVYGTLEEVWDCVKPAVGGLRVKWDENVTGFEIIQSITDTLCVSRTSTPSAAMKLISPRDFVDLVLVKRYEDGTISSNATHVEHPLCPPKPGFVRGFNHPCGCFCEPLPGEPTKTNLVTFFHTDLSGYLPQNVVDSFFPRSMTRFYANLQKAVKQFHE","proteinLength":"Full Length","predictedMolecularWeight":"26.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":213,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NSY2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STARD5 also known as StAR-related lipid transfer domain protein 5 is an important player in intracellular cholesterol transport. It functions as a START domain containing protein facilitating the transfer of cholesterol and other lipids between intracellular membranes. With a molecular mass of approximately 23 kDa STARD5 displays a specific pattern of expression in tissues. It is highly expressed in the liver kidney and spleen where it plays a role in cellular lipid regulation.
Biological function summary

The transfer of cholesterol and lipids by STARD5 helps maintain cellular lipid homeostasis. It is not known to form part of a complex but operates independently to ensure that cholesterol levels are balanced within cells. This activity supports cell membrane integrity and the synthesis of steroid hormones and bile acids. By regulating these processes STARD5 plays a significant function in maintaining cell health and metabolism.

Pathways

The activity of STARD5 is critical in the cholesterol transport and metabolism pathway. It works closely with proteins such as NPC1 and NPC2 which also facilitate cholesterol trafficking. This involvement aligns STARD5 with the lysosomal storage pathway highlighting its role in managing cholesterol storage and mobilization within cells.

Altered function or expression of STARD5 links to conditions like Niemann-Pick disease type C and obesity-related dyslipidemia. Niemann-Pick disease type C is closely tied to disrupted cholesterol transport where STARD5's role intersects with NPC1 and NPC2 proteins both known for their involvement in this lysosomal disorder. In obesity-related dyslipidemia the protein's regulation of cholesterol levels can impact lipid profiles influencing disease development and progression.
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Specifications

Form

Liquid

Additional notes

ab176085 is purified using conventional chromatography techniques.

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General info

Function

May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

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Product protocols

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Target data

May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).
See full target information StAR-related lipid transfer protein 5
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