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AB166097

Recombinant Human STEAP2 protein (GST tag N-Terminus)

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Recombinant Human STEAP2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 490 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

PCANAP1, STAMP1, UNQ6507/PRO23203, STEAP2, Metalloreductase STEAP2, Prostate cancer-associated protein 1, Protein up-regulated in metastatic prostate cancer, Six-transmembrane epithelial antigen of prostate 2, SixTransMembrane protein of prostate 1, PUMPCn

1 Images
SDS-PAGE - Recombinant Human STEAP2 protein (GST tag N-Terminus) (AB166097)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human STEAP2 protein (GST tag N-Terminus) (AB166097)

ab166097 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q8NFT2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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SDS-PAGE - Recombinant Human ZNF358 protein (GST tag N-Terminus) (AB165455)

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SDS-PAGE - Recombinant Human Zinc finger protein 276 (GST tag N-Terminus) (AB164919)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":490,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8NFT2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STEAP2 also known as six transmembrane epithelial antigen of the prostate 2 is a metalloreductase with a mass of about 56 kDa. It facilitates the reduction of metal ions in a process dependent on FAD and NADPH. Expressed mainly in the prostate STEAP2 also appears in other tissues at lower levels. This protein exhibits a tendency to localize to cellular membranes and endocytic vesicles aiding in the uptake and processing of metal ions like iron and copper which are important for cellular activities.
Biological function summary

STEAP2 plays a role in ion homeostasis and cellular proliferation. It acts as part of a complex involving other STEAP family members contributing to the reduction of metal ions essential for various cellular processes. Its ability to mediate electron transport is important for maintaining the balance of redox reactions critical for normal cellular functions. The involvement in cellular proliferation ties STEAP2 to tissue development and repair mechanisms.

Pathways

STEAP2 interacts within metal ion transport and homeostasis pathways influencing processes like oxidative stress responses. It associates with proteins such as ferritin important for iron storage and metallothioneins linked to metal detoxification. These interactions are essential for regulating intracellular metal ion concentrations thereby impacting cellular health and function. It also relates to cellular growth pathways connecting it to certain growth factor signals.

Abnormal STEAP2 expression links to prostate cancer and other proliferative disorders. Its overexpression in prostate cancer cells correlates with increased tumor aggressiveness and progression. STEAP2 interacts with other oncogenic proteins such as PSA (prostate-specific antigen) which are critical in the diagnosis and progression monitoring of prostate cancer. Additionally alterations in STEAP2 function may affect systemic metal ion homeostasis potentially contributing to disorders like hemochromatosis although this link is less well-defined in clinical settings.
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Specifications

Form

Liquid

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General info

Function

Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity).

Sequence similarities

Belongs to the STEAP family.

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Product protocols

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Target data

Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity).
See full target information STEAP2
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