Recombinant Human STF2D1 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STF2D1 also known as Spindle and Kinetochore Associated Complex Subunit 2 is a protein with a molecular weight of around 48 kDa. It is expressed in various tissues notably in highly proliferative cells. STF2D1 interacts with microtubules during cell division playing a mechanical role in the spindle assembly and positioning. It ensures proper chromosome segregation and mitotic progression essential for maintaining genomic stability.

Biological function summary

STF2D1 is involved in the regulation of the mitotic spindle apparatus. It is an integral part of the spindle-kinetochore complex where it contributes to the attachment of microtubules to kinetochores. This interaction is critical for chromosome alignment and segregation during mitosis influencing the cell cycle's fidelity. Alterations in STF2D1 can affect cellular proliferation and may have consequences on tissue homeostasis.

Pathways

STF2D1 is an important component in cell cycle regulation particularly during the mitotic checkpoint. It interacts with key cell cycle proteins like Aurora B kinase and BubR1 influencing the spindle checkpoint pathway. These interactions help monitor and correct improper kinetochore-microtubule attachments to prevent aneuploidy. STF2D1's role in these pathways emphasizes its importance in ensuring accurate cell division and genetic stability.

Disruptions in STF2D1 function are linked to cancer and congenital aneuploidy disorders. In certain cancers STF2D1 may become overexpressed contributing to unchecked cell division and tumor progression. It is related to proteins like p53 and BCL2 through these malignancy pathways which affect apoptosis and cell cycle arrest. Understanding STF2D1's role in these diseases can inform therapeutic approaches that target cell division abnormalities.