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AB126929

Recombinant Human STK25 protein

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Recombinant Human STK25 protein is a Human Full Length protein, in the 1 to 426 aa range, expressed in Baculovirus infected Sf9 cells, with >75%, suitable for SDS-PAGE.

View Alternative Names

SOK1, YSK1, STK25, Serine/threonine-protein kinase 25, Ste20-like kinase, Sterile 20/oxidant stress-response kinase 1, SOK-1, Ste20/oxidant stress response kinase 1

1 Images
SDS-PAGE - Recombinant Human STK25 protein (AB126929)
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SDS-PAGE - Recombinant Human STK25 protein (AB126929)

SDS-PAGE analysis of ab126929.

Key facts

Purity

>75% Densitometry

Expression system

Baculovirus infected Sf9 cells

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O00506

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.0039% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"74 kDa","actualMolecularWeight":null,"aminoAcidEnd":426,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"O00506","tags":[]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STK25 also known as Serine/Threonine Kinase 25 or YSK1 is an enzyme with a molecular weight of approximately 59 kDa. It functions as a serine/threonine kinase and plays a role in the regulation of various cellular processes. STK25 is present in many tissues but its expression levels are high in the brain liver and testis. This kinase is involved in several signaling pathways that modulate cell dynamics and organization influencing cellular architecture and function.
Biological function summary

STK25 participates in signaling pathways that govern structural cellular dynamics. It acts independently or as part of a larger protein complex to control cell polarity and morphological changes. STK25 can influence actin cytoskeleton reorganization which affects cell shape and movement. It holds importance for processes related to cell adhesion and cell-matrix interactions important for maintaining proper cell structures and responses to environmental stimuli.

Pathways

STK25 integrates into key signaling cascades. It plays a role in the Hippo signaling pathway which regulates organ size and suppresses tumor growth. STK25 interacts with other proteins such as MST1/2 to influence this pathway's activity. Additionally it associates with the MAPK signaling pathway modulating cellular responses like proliferation and stress resistance. Through these interactions STK25 connects to broader networks influencing cellular behavior and responses.

STK25 has links to neurodegenerative disorders and diabetes. Studies have shown its contribution to the development of Alzheimer's disease where it may interact with tau protein leading to tau hyperphosphorylation and aggregation. Moreover STK25 relates to metabolic syndromes particularly insulin resistance by associating with pathways affecting glucose homeostasis. These relationships suggest STK25's involvement in both neurological and metabolic health.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed : 18782753).

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

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Product protocols

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Target data

Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed : 18782753).
See full target information STK25
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