Recombinant human STK38 protein
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant human STK38 protein is a Human Full Length protein, expressed in Baculovirus infected insect cells, with >70%, suitable for SDS-PAGE, FuncS.
View Alternative Names
NDR1, STK38, Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1
- FuncS
Unknown
Functional Studies - Recombinant human STK38 protein (AB101549)
The specific activity of STK38 (ab101549) was determined to be 3.4 nmol/min/mg as per activity assay protocol
- FuncS
Unknown
Functional Studies - Recombinant human STK38 protein (AB101549)
Kinase Assay demonstrating specific activity of ab101549.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human STK38 protein (AB101549)
SDS-PAGE showing ab101549 at approximately 81kDa.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human STK38 protein (AB101549)
SDS PAGE analysis of ab101549
Complementary Products
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
STK38 is essential for regulating apoptosis and cell cycle progression. It acts as part of a larger signaling complex engaging in interactions with different proteins to exert its effects. Phosphorylation by STK38 often leads to activation or inhibition of downstream targets influencing cell survival and division. It can interact with MOB1 and LATS1/2 which highlights its role in the Hippo signaling pathway important for controlling organ size and suppressing tumors.
Pathways
The STK38 protein integrates itself into the Hippo and mTOR pathways. In the Hippo pathway its interactions with MOB1 and LATS proteins are important for regulating organ size and maintaining balance between cell growth and death. In the mTOR pathway STK38 influences metabolic processes and cell growth by modifying signal transduction that is critical for cellular homeostasis. These pathways are vital for normal cellular function and highlight the regulatory versatility of STK38.
Specifications
Form
Liquid
Additional notes
The purity was determined to be >75% by densitometry. Affinity purified.
General info
Function
Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed : 12493777, PubMed : 15197186, PubMed : 17906693, PubMed : 7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed : 12493777, PubMed : 15197186, PubMed : 17906693, PubMed : 7761441). Acts as an ufmylation 'reader' in a kinase-independent manner : specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed : 32537488).
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Post-translational modifications
ISGylated.. Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B.
Subcellular localisation
Nucleus
Target data
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com