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AB179956

Recombinant Human STK40 protein (GST tag N-Terminus)

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Recombinant Human STK40 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 435 aa range, expressed in Baculovirus infected Sf9 cells, with >95%, suitable for SDS-PAGE, WB.
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SDS-PAGE - Recombinant Human STK40 protein (GST tag N-Terminus) (AB179956)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human STK40 protein (GST tag N-Terminus) (AB179956)

SDS-PAGE analysis of ab179956.

Key facts

Purity

>95% Densitometry

Affinity purified.

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE

applications

Biologically active

No

Accession

Q8N2I9-1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

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Complementary Products

Reagents, Controls & Accessories

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Assay Kits

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cAMP Assay Kit (Competitive ELISA, Fluorometric)

ELISA - cAMP Assay Kit (Competitive ELISA, Fluorometric) (AB138880)

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Assay Kits

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cAMP Assay Kit (Competitive ELISA)

Competitive ELISA - cAMP Assay Kit (Competitive ELISA) (AB290713)

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Primary Antibodies

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Anti-cAMP antibody [EP8471]

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ELISA - Anti-cAMP antibody [EP8471] (AB134901)

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Primary Antibodies

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Anti-cAMP Protein Kinase Catalytic subunit antibody [EP2102Y]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MKRRASDRGAGETSARAKALGSGISGNNAKRAGPFILGPRLGNSPVPSIVQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIASWQSLSSLSGPLQVVPDIDDQMSNADSSQEAKVTEECSQYEFENYMRQQLLLAEEKSSIHDARSWVPKRQFGSAPPVRRLGHDAQPMTSLDTAILAQRYLRK","proteinLength":"Full Length","predictedMolecularWeight":"74 kDa","actualMolecularWeight":null,"aminoAcidEnd":435,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q8N2I9","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STK40 also known as Serine/Threonine Kinase 40 or protein-cancelled testis is an important kinase involved in several cellular processes. This protein has a mass of approximately 52 kDa. STK40 is mainly expressed in embryonic tissues and adult testis but also observed in many other tissues highlighting its various roles during development and in adult organisms. STK40 functions by phosphorylating target proteins which affects their function and regulates their activities within the cell.
Biological function summary

STK40 influences cell differentiation and development. It forms part of signaling complexes interacting with various other proteins to impart its effect. STK40 influences pluripotency in stem cells by modulating transcription factors and signaling pathways critical for maintaining a stable differentiation state. Moreover STK40 is shown to play a role in adipogenesis by affecting pathways that control fat cell formation and distribution.

Pathways

STK40 functions actively within several signaling cascades notably the MAPK and Wnt pathways. In the MAPK pathway it coordinates with proteins like MAP3K7 to control transcriptional activation linked to cellular stress responses and differentiation processes. In the Wnt signaling pathway STK40 influences the stabilization of beta-catenin a central protein in regulating gene expression related to cell proliferation and fate decisions.

STK40 has connections to cancer and metabolic syndromes. Dysregulation of STK40 expression or function can lead to improper cell differentiation and proliferation contributing to tumorigenesis particularly in testicular cancer. In metabolic disorders such as obesity STK40’s role in adipogenesis can affect fat deposition and might interlink with other proteins like PPARγ which further influences lipid metabolism and insulin sensitivity. Understanding STK40’s role in these conditions highlights its potential as a therapeutic target.
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Product protocols

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Target data

May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
See full target information STK40

Alternative Names

SGK495, SHIK, STK40, Serine/threonine-protein kinase 40, SINK-homologous serine/threonine-protein kinase, Sugen kinase 495, SgK495
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