Recombinant Human Sts1 protein is a Human Full Length protein, in the 1 to 649 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M A Q Y G H P S P L G M A A R E E L Y S K V T P R R N R Q Q R P G T I K H G S A L D V L L S M G F P R A R A Q K A L A S T G G R S V Q A A C D W L F S H V G D P F L D D P L P R E Y V L Y L R P T G P L A Q K L S D F W Q Q S K Q I C G K N K A H N I F P H I T L C Q F F M C E D S K V D A L G E A L Q T T V S R W K C K F S A P L P L E L Y T S S N F I G L F V K E D S A E V L K K F A A D F A A E A A S K T E V H V E P H K K Q L H V T L A Y H F Q A S H L P T L E K L A Q N I D V K L G C D W V A T I F S R D I R F A N H E T L Q V I Y P Y T P Q N D D E L E L V P G D F I F M S P M E Q T S T S E G W I Y G T S L T T G C S G L L P E N Y I T K A D E C S T W I F H G S Y S I L N T S S S N S L T F G D G V L E R R P Y E D Q G L G E T T P L T I I C Q P M Q P L R V N S Q P G P Q K R C L F V C R H G E R M D V V F G K Y W L S Q C F D A K G R Y I R T N L N M P H S L P Q R S G G F R D Y E K D A P I T V F G C M Q A R L V G E A L L E S N T I I D H V Y C S P S L R C V Q T A H N I L K G L Q Q E N H L K I R V E P G L F E W T K W V A G S T L P A W I P P S E L A A A N L S V D T T Y R P H I P I S K L V V S E S Y D T Y I S R S F Q V T K E I I S E C K S K G N N I L I V A H A S S L E A C T C Q L Q G L S P Q N S K D F V Q M V R K I P Y L G F C S C E E L G E T G I W Q L T D P P I L P L T H G P T G G F N W R E T L L Q E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
Alternative names
KIAA1959, STS1, UBASH3B, Ubiquitin-associated and SH3 domain-containing protein B, Cbl-interacting protein p70, Suppressor of T-cell receptor signaling 1, T-cell ubiquitin ligand 2, Tyrosine-protein phosphatase STS1/TULA2, STS-1, TULA-2
Recommended products
Recombinant Human Sts1 protein is a Human Full Length protein, in the 1 to 649 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q8TF42-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A Q Y G H P S P L G M A A R E E L Y S K V T P R R N R Q Q R P G T I K H G S A L D V L L S M G F P R A R A Q K A L A S T G G R S V Q A A C D W L F S H V G D P F L D D P L P R E Y V L Y L R P T G P L A Q K L S D F W Q Q S K Q I C G K N K A H N I F P H I T L C Q F F M C E D S K V D A L G E A L Q T T V S R W K C K F S A P L P L E L Y T S S N F I G L F V K E D S A E V L K K F A A D F A A E A A S K T E V H V E P H K K Q L H V T L A Y H F Q A S H L P T L E K L A Q N I D V K L G C D W V A T I F S R D I R F A N H E T L Q V I Y P Y T P Q N D D E L E L V P G D F I F M S P M E Q T S T S E G W I Y G T S L T T G C S G L L P E N Y I T K A D E C S T W I F H G S Y S I L N T S S S N S L T F G D G V L E R R P Y E D Q G L G E T T P L T I I C Q P M Q P L R V N S Q P G P Q K R C L F V C R H G E R M D V V F G K Y W L S Q C F D A K G R Y I R T N L N M P H S L P Q R S G G F R D Y E K D A P I T V F G C M Q A R L V G E A L L E S N T I I D H V Y C S P S L R C V Q T A H N I L K G L Q Q E N H L K I R V E P G L F E W T K W V A G S T L P A W I P P S E L A A A N L S V D T T Y R P H I P I S K L V V S E S Y D T Y I S R S F Q V T K E I I S E C K S K G N N I L I V A H A S S L E A C T C Q L Q G L S P Q N S K D F V Q M V R K I P Y L G F C S C E E L G E T G I W Q L T D P P I L P L T H G P T G G F N W R E T L L Q E
- Accession
- Q8TF42
- Protein length
- Full Length
- Amino acids
- 1 to 649
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Sts1 also known as Suppressor of T-cell receptor signaling 1 is a protein with a mass of approximately 72 kDa. It functions mechanically by serving as a negative regulator in T-cell receptor signaling pathways. Sts1 contains N-terminal SH3 domains and C-terminal ubiquitin-associated domains essential for its regulatory activity. Expression of Sts1 is widespread with notable abundance in immune cells such as T-cells and B-cells. These structural features enable Sts1 to interact with various signaling molecules.
- Biological function summary
In cellular processes Sts1 plays a role in modulating immune responses. It interacts with signaling proteins including the ZAP-70 kinase which is central to T-cell receptor signaling. Sts1 forms a complex with several proteins involved in the ubiquitination process which marks proteins for degradation or alters their function. By this Sts1 influences the strength and duration of signals received by the immune cells ensuring proper immune system function.
- Pathways
Sts1 serves in the T-cell receptor signaling pathway and contributes to the modulation of the immune response. The protein is closely linked to ubiquitin-proteasome system pathways which govern protein turnover and cellular regulation. In these pathways Sts1 associates with proteins like c-Cbl which are involved in the ubiquitination and degradation of signaling intermediates.
- Associated diseases and disorders
Deficiencies or dysregulation of Sts1 are often associated with autoimmune diseases and certain lymphomas. Its interplay with proteins like c-Cbl or ZAP-70 can result in aberrant T-cell activation and uncontrolled proliferation. This abnormal signaling could lead to autoimmune disorders such as systemic lupus erythematosus or contribute to the development of B-cell lymphomas where immune regulation breaks down.
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1 product image
SDS-PAGE - Recombinant Human Sts1 protein (ab153560)
ab153560 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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