Recombinant Human STX11 protein (denatured) is a Human Full Length protein, in the 1 to 287 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S H M K D R L A E L L D L S K Q Y D Q Q F P D G D D E F D S P H E D I V F E T D H I L E S L Y R D I R D I Q D E N Q L L V A D V K R L G K Q N A R F L T S M R R L S S I K R D T N S I A K A I K A R G E V I H C K L R A M K E L S E A A E A Q H G P H S A V A R I S R A Q Y N A L T L T F Q R A M H D Y N Q A E M K Q R D N C K I R I Q R Q L E I M G K E V S G D Q I E D M F E Q G K W D V F S E N L L A D V K G A R A A L N E I E S R H R E L L R L E S R I R D V H E L F L Q M A V L V E K Q A D T L N V I E L N V Q K T V D Y T G Q A K A Q V R K A V Q Y E E K N P C R T L C C F C C P C L K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
Alternative names
Syntaxin-11, STX11
Recommended products
Recombinant Human STX11 protein (denatured) is a Human Full Length protein, in the 1 to 287 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- O75558-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S H M K D R L A E L L D L S K Q Y D Q Q F P D G D D E F D S P H E D I V F E T D H I L E S L Y R D I R D I Q D E N Q L L V A D V K R L G K Q N A R F L T S M R R L S S I K R D T N S I A K A I K A R G E V I H C K L R A M K E L S E A A E A Q H G P H S A V A R I S R A Q Y N A L T L T F Q R A M H D Y N Q A E M K Q R D N C K I R I Q R Q L E I M G K E V S G D Q I E D M F E Q G K W D V F S E N L L A D V K G A R A A L N E I E S R H R E L L R L E S R I R D V H E L F L Q M A V L V E K Q A D T L N V I E L N V Q K T V D Y T G Q A K A Q V R K A V Q Y E E K N P C R T L C C F C C P C L K
- Accession
- O75558
- Protein length
- Full Length
- Predicted molecular weight
- 35.8 kDa
- Amino acids
- 1 to 287
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
- Sequence similarities
Belongs to the syntaxin family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Syntaxin 11 (STX11) is a member of the syntaxin family known as an important component in vesicle trafficking. This protein has a molecular mass of about 33 kDa. STX11 is mainly expressed in immune system cells including natural killer (NK) cells and macrophages. It plays a significant role in vesicle fusion processes by mediating the assembly and disassembly of SNARE complexes which are critical for vesicular transport and membrane fusion.
- Biological function summary
Syntaxin 11 acts within the immune system to mediate secretory functions. It forms part of the SNARE complex and partners with other SNARE proteins to facilitate the exocytosis of cytotoxic granules from NK cells and cytotoxic T lymphocytes. This process is essential for immune cell-mediated destruction of infected or malignant cells. STX11 enables the regulation of immune responses by controlling vesicle docking and fusion during immune cell activation.
- Pathways
The role of STX11 connects to critical immune response pathways. It plays a role in the regulation of the cytotoxic granule exocytosis pathway. This protein interacts with MUNC18-2 and other SNARE-related proteins facilitating vesicle transport and membrane fusion processes. STX11 is also involved in the modulation of pathways that oversee immune cell cytotoxicity and inflammatory responses.
- Associated diseases and disorders
Syntaxin 11 shows a connection to hemophagocytic lymphohistiocytosis (HLH) a severe immune dysregulation disorder. Alterations in STX11 have been linked to familial HLH where defective granule exocytosis impairs the immune system's ability to control inflammation leading to excessive immune activation. Interactions between STX11 and other proteins such as perforin are important in understanding HLH pathogenesis. Studies also suggest a potential connection to other immune system disorders though research continues to explore these relationships.
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1 product image
SDS-PAGE - Recombinant Human STX11 protein (denatured) (ab126662)
15% SDS-PAGE analysis of ab126662 (3 µg).
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