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AB126662

Recombinant Human STX11 protein (denatured)

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Recombinant Human STX11 protein (denatured) is a Human Full Length protein, in the 1 to 287 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

View Alternative Names

Syntaxin-11, STX11

1 Images
SDS-PAGE - Recombinant Human STX11 protein (denatured) (AB126662)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human STX11 protein (denatured) (AB126662)

15% SDS-PAGE analysis of ab126662 (3 µg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O75558

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMKDRLAELLDLSKQYDQQFPDGDDEFDSPHEDIVFETDHILESLYRDIRDIQDENQLLVADVKRLGKQNARFLTSMRRLSSIKRDTNSIAKAIKARGEVIHCKLRAMKELSEAAEAQHGPHSAVARISRAQYNALTLTFQRAMHDYNQAEMKQRDNCKIRIQRQLEIMGKEVSGDQIEDMFEQGKWDVFSENLLADVKGARAALNEIESRHRELLRLESRIRDVHELFLQMAVLVEKQADTLNVIELNVQKTVDYTGQAKAQVRKAVQYEEKNPCRTLCCFCCPCLK","proteinLength":"Full Length","predictedMolecularWeight":"35.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":287,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O75558","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Syntaxin 11 (STX11) is a member of the syntaxin family known as an important component in vesicle trafficking. This protein has a molecular mass of about 33 kDa. STX11 is mainly expressed in immune system cells including natural killer (NK) cells and macrophages. It plays a significant role in vesicle fusion processes by mediating the assembly and disassembly of SNARE complexes which are critical for vesicular transport and membrane fusion.
Biological function summary

Syntaxin 11 acts within the immune system to mediate secretory functions. It forms part of the SNARE complex and partners with other SNARE proteins to facilitate the exocytosis of cytotoxic granules from NK cells and cytotoxic T lymphocytes. This process is essential for immune cell-mediated destruction of infected or malignant cells. STX11 enables the regulation of immune responses by controlling vesicle docking and fusion during immune cell activation.

Pathways

The role of STX11 connects to critical immune response pathways. It plays a role in the regulation of the cytotoxic granule exocytosis pathway. This protein interacts with MUNC18-2 and other SNARE-related proteins facilitating vesicle transport and membrane fusion processes. STX11 is also involved in the modulation of pathways that oversee immune cell cytotoxicity and inflammatory responses.

Syntaxin 11 shows a connection to hemophagocytic lymphohistiocytosis (HLH) a severe immune dysregulation disorder. Alterations in STX11 have been linked to familial HLH where defective granule exocytosis impairs the immune system's ability to control inflammation leading to excessive immune activation. Interactions between STX11 and other proteins such as perforin are important in understanding HLH pathogenesis. Studies also suggest a potential connection to other immune system disorders though research continues to explore these relationships.
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Specifications

Form

Liquid

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General info

Function

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.

Sequence similarities

Belongs to the syntaxin family.

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Product protocols

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Target data

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
See full target information STX11
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Complementary Products

Primary Antibodies

AB216046

Anti-STX11 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STX11 antibody (AB216046)

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