Recombinant Human SUGT1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SUGT1 also known as Suppressor of G2 allele of SKP1 homolog is a protein widely recognized for its role in cellular processes. It has a mass of approximately 43 kDa. Researchers typically find SUGT1 expressed in a variety of tissues with significant levels noted in the brain and reproductive organs. Its presence indicates key functions in diverse cellular environments contributing to its significance in biological research.

Biological function summary

In cellular operations SUGT1 works as a co-chaperone with HSP90 forming complexes that stabilize proteins and assist in protein folding. This interaction is critical for maintaining the proper functioning of proteins like kinases and transcription factors. SUGT1's role in forming protein complexes shows its influence in cellular stability and stress responses which helps cells combat various stresses they encounter.

Pathways

Researchers place SUGT1 within important frameworks like the Wnt signaling and kinetochore assembly pathways. In the Wnt pathway SUGT1 modulates the activity of other proteins such as beta-catenin which play roles in cell cycle regulation and embryonic development. SUGT1 associates with proteins like CCT and HSP90 via these pathways guiding processes critical for normal cell function and division.

SUGT1 involvement becomes noticeable in cancer and neurodegenerative diseases. In certain cancers altered SUGT1 activity can affect the stabilization of proteins involved in cell growth potentially leading to unchecked cell proliferation. Moreover its connection with proteins such as p53 demonstrates its role in pathways linked to cancer progression. Additionally in neurodegenerative diseases the interaction between SUGT1 and proteins like tau indicates its potential role in the pathophysiology of disorders like Alzheimer's disease highlighting the importance of understanding its functions to explore therapeutic interventions.