Recombinant Human SUGT1 protein is a Human Full Length protein, in the 2 to 333 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
M A S M T G G Q E N G R G E F A A A A A G T A T S Q R F F Q S F S D A L I D E D P Q A A L E E L T K A L E Q K P D D A Q Y Y C Q R A Y C H I L L G N Y C V A V A D A K K S L E L N P N N S T A M L R K G I C E Y H E K N Y A A A L E T F T E G Q K L D S A D A N F S V W I K R C Q E A Q N G S E S E V W T H Q S K I K Y D W Y Q T E S Q V V I T L M I K N V Q K N D V N V E F S E K E L S A L V K L P S G E D Y N L K L E L L H P I I P E Q S T F K V L S T K I E I K L K K P E A V R W E K L E G Q G D V P T P K Q F V A D V K N L Y P S S S P Y T R N W D K L V G E I K E E E K N E K L E G D A A L N R L F Q Q I Y S D G S D E V K R A M N K S F M E S G G T V L S T N W S D V G K R K V E I N P P D D M E W K K Y
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
Protein SGT1 homolog, Protein 40-6-3, Sgt1, Suppressor of G2 allele of SKP1 homolog, SUGT1
Recombinant Human SUGT1 protein is a Human Full Length protein, in the 2 to 333 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
pH: 8
Constituents: 0.32% Tris HCl
This protein was expressed in E. coli as inclusion bodies, refolded using unique “temperature shift inclusion body refolding” technology and chromatographically purified.
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
Belongs to the SGT1 family.
Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.
SUGT1 also known as Suppressor of G2 allele of SKP1 homolog is a protein widely recognized for its role in cellular processes. It has a mass of approximately 43 kDa. Researchers typically find SUGT1 expressed in a variety of tissues with significant levels noted in the brain and reproductive organs. Its presence indicates key functions in diverse cellular environments contributing to its significance in biological research.
In cellular operations SUGT1 works as a co-chaperone with HSP90 forming complexes that stabilize proteins and assist in protein folding. This interaction is critical for maintaining the proper functioning of proteins like kinases and transcription factors. SUGT1's role in forming protein complexes shows its influence in cellular stability and stress responses which helps cells combat various stresses they encounter.
Researchers place SUGT1 within important frameworks like the Wnt signaling and kinetochore assembly pathways. In the Wnt pathway SUGT1 modulates the activity of other proteins such as beta-catenin which play roles in cell cycle regulation and embryonic development. SUGT1 associates with proteins like CCT and HSP90 via these pathways guiding processes critical for normal cell function and division.
SUGT1 involvement becomes noticeable in cancer and neurodegenerative diseases. In certain cancers altered SUGT1 activity can affect the stabilization of proteins involved in cell growth potentially leading to unchecked cell proliferation. Moreover its connection with proteins such as p53 demonstrates its role in pathways linked to cancer progression. Additionally in neurodegenerative diseases the interaction between SUGT1 and proteins like tau indicates its potential role in the pathophysiology of disorders like Alzheimer's disease highlighting the importance of understanding its functions to explore therapeutic interventions.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com