Recombinant Human Sulfite oxidase protein is a Human Full Length protein, in the 80 to 545 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S E S T H I Y T K E E V S S H T S P E T G I W V T L G S E V F D V T E F V D L H P G G P S K L M L A A G G P L E P F W A L Y A V H N Q S H V R E L L A Q Y K I G E L N P E D K V A P T V E T S D P Y A D D P V R H P A L K V N S Q R P F N A E P P P E L L T E N Y I T P N P I F F T R N H L P V P N L D P D T Y R L H V V G A P G G Q S L S L S L D D L H N F P R Y E I T V T L Q C A G N R R S E M T Q V K E V K G L E W R T G A I S T A R W A G A R L C D V L A Q A G H Q L C E T E A H V C F E G L D S D P T G T A Y G A S I P L A R A M D P E A E V L L A Y E M N G Q P L P R D H G F P V R V V V P G V V G A R H V K W L G R V S V Q P E E S Y S H W Q R R D Y K G F S P S V D W E T V D F D S A P S I Q E L P V Q S A I T E P R D G E T V E S G E V T I K G Y A W S G G G R A V I R V D V S L D G G L T W Q V A K L D G E E Q R P R K A W A W R L W Q L K A P V P A G Q K E L N I V C K A V D D G Y N V Q P D T V A P I W N L R G V L S N A W H R V H V Y V S P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
Alternative names
SUOX
Recommended products
Recombinant Human Sulfite oxidase protein is a Human Full Length protein, in the 80 to 545 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P51687-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 69% PBS, 30% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S E S T H I Y T K E E V S S H T S P E T G I W V T L G S E V F D V T E F V D L H P G G P S K L M L A A G G P L E P F W A L Y A V H N Q S H V R E L L A Q Y K I G E L N P E D K V A P T V E T S D P Y A D D P V R H P A L K V N S Q R P F N A E P P P E L L T E N Y I T P N P I F F T R N H L P V P N L D P D T Y R L H V V G A P G G Q S L S L S L D D L H N F P R Y E I T V T L Q C A G N R R S E M T Q V K E V K G L E W R T G A I S T A R W A G A R L C D V L A Q A G H Q L C E T E A H V C F E G L D S D P T G T A Y G A S I P L A R A M D P E A E V L L A Y E M N G Q P L P R D H G F P V R V V V P G V V G A R H V K W L G R V S V Q P E E S Y S H W Q R R D Y K G F S P S V D W E T V D F D S A P S I Q E L P V Q S A I T E P R D G E T V E S G E V T I K G Y A W S G G G R A V I R V D V S L D G G L T W Q V A K L D G E E Q R P R K A W A W R L W Q L K A P V P A G Q K E L N I V C K A V D D G Y N V Q P D T V A P I W N L R G V L S N A W H R V H V Y V S P
- Accession
- P51687
- Protein length
- Full Length
- Predicted molecular weight
- 53.9 kDa
- Amino acids
- 80 to 545
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab202605 was purified by using conventional chromatography techniques.
General info
- Function
Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
- Subcellular localisation
- Mitochondrion intermembrane space
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Previously labelled as SUOX.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Sulfite oxidase also known as SUOX has a molecular mass of approximately 57 kDa and plays a critical role in the conversion of sulfite to sulfate. This enzyme is located in the mitochondria of cells across various tissues but is prominently expressed in the liver and kidney. Its activity depends on molybdenum and heme cofactors rendering it an important player in cellular redox reactions.
- Biological function summary
Sulfite oxidase acts in the detoxification process of sulfur-containing amino acids. It functions as a monomer and ensures that the potentially harmful intermediate sulfite is efficiently converted to the harmless end product sulfate which can then be excreted. This detoxification is important for cellular health and prevents accumulation of sulfite which could lead to oxidative damage.
- Pathways
Sulfite oxidase plays an important part in two major metabolic processes: the sulfur amino acid detoxification pathway and the metabolic pathway of the degradation of branched-chain amino acids. It works together with cytochrome c in the electron transport chain to facilitate electron transfer. Sulfite oxidase’s function ensures proper catabolism of amino acids and assists in maintaining cellular homeostasis.
- Associated diseases and disorders
Sulfite oxidase deficiency can cause severe neurological impairment and developmental delay often linked to sulfite oxidase deficiency disorder itself. This genetic disorder results from mutations in the SUOX gene disrupting proper enzyme function. Associations have also been highlighted with neurological conditions where oxidative stress plays a part implicating this enzyme’s failure to properly regulate sulfite levels. Additionally its interactions with the molybdenum cofactor highlight connections to molybdenum cofactor deficiency further illustrating its importance in human health.
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1 product image
SDS-PAGE - Recombinant Human Sulfite oxidase protein (ab202605)
15% SDS-PAGE using 3 μg of ab202605.
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