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AB109961

Recombinant Human SULT1A2 protein

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Recombinant Human SULT1A2 protein is a Human Full Length protein, in the 1 to 295 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

STP2, SULT1A2, Sulfotransferase 1A2, ST1A2, Aryl sulfotransferase 2, Phenol sulfotransferase 2, Phenol-sulfating phenol sulfotransferase 2, P-PST 2

1 Images
SDS-PAGE - Recombinant Human SULT1A2 protein (AB109961)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SULT1A2 protein (AB109961)

15% SDS-PAGE analysis of 3μg ab109961.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P50226

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.058% Sodium chloride, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMELIQDISRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL","proteinLength":"Full Length","predictedMolecularWeight":"36.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":295,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P50226","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SULT1A2 also known as Sulfotransferase Family 1A Member 2 is an enzyme involved in the sulfonation pathway. This enzyme has a molecular weight of approximately 34 kDa and is expressed mainly in the liver as well as other tissues like the intestines and lungs. Mechanically SULT1A2 functions by transferring sulfate groups to various substrates including hormones drugs and xenobiotic compounds. This enzymatic activity plays an important role in increasing the solubility of these molecules facilitating their excretion from the body.
Biological function summary

The sulfonation activity of SULT1A2 contributes to the regulation and metabolism of hormones and drugs. It is not part of a larger complex but works independently to modulate hormone activity and detoxify xenobiotics. This enzyme's ability to modify the biochemical properties of its substrates is essential in cellular regulation and homeostasis impacting physiological processes in humans.

Pathways

The activity of SULT1A2 is involved in the metabolism and detoxification pathways. It closely interacts with other phase II detoxification enzymes such as those in the UDP-glucuronosyltransferase family. Through these pathways SULT1A2 helps transform hydrophobic compounds into more hydrophilic forms aiding in their elimination from the organism. The enzyme's role in hormone homeostasis connects it to pathways involving hormone regulation and action.

SULT1A2 has links to certain cancers and drug metabolism disorders. In cancers altered expression levels of SULT1A2 may affect the balance of hormones potentially contributing to oncogenesis. It has also been noted in disorders of drug metabolism where malfunction of SULT1A2 can impact the efficacy and toxicity of administered medications. The enzyme interacts with cytochrome P450 family proteins which play roles in the metabolic pathways of both drugs and endogenous compounds.
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Specifications

Form

Liquid

Additional notes

ab109961 was purified using conventional chromatography techniques.

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General info

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Sequence similarities

Belongs to the sulfotransferase 1 family.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
See full target information SULT1A2
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Proteins & Peptides

AB173058

Recombinant Human SULT1A2 protein

proteins-peptides

recombinant-human-sult1a2-protein-ab173058

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