JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB173058

Recombinant Human SULT1A2 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human SULT1A2 protein is a Human Full Length protein, in the 1 to 295 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

STP2, SULT1A2, Sulfotransferase 1A2, ST1A2, Aryl sulfotransferase 2, Phenol sulfotransferase 2, Phenol-sulfating phenol sulfotransferase 2, P-PST 2

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, HPLC

applications

Biologically active

No

Accession

P50226

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.58% Sodium chloride, 0.24% Tris

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column
style
left-column

Sequence info

[{"sequence":"MELIQDISRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL","proteinLength":"Full Length","predictedMolecularWeight":"36.47 kDa","actualMolecularWeight":null,"aminoAcidEnd":295,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P50226","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SULT1A2 also known as Sulfotransferase Family 1A Member 2 is an enzyme involved in the sulfonation pathway. This enzyme has a molecular weight of approximately 34 kDa and is expressed mainly in the liver as well as other tissues like the intestines and lungs. Mechanically SULT1A2 functions by transferring sulfate groups to various substrates including hormones drugs and xenobiotic compounds. This enzymatic activity plays an important role in increasing the solubility of these molecules facilitating their excretion from the body.
Biological function summary

The sulfonation activity of SULT1A2 contributes to the regulation and metabolism of hormones and drugs. It is not part of a larger complex but works independently to modulate hormone activity and detoxify xenobiotics. This enzyme's ability to modify the biochemical properties of its substrates is essential in cellular regulation and homeostasis impacting physiological processes in humans.

Pathways

The activity of SULT1A2 is involved in the metabolism and detoxification pathways. It closely interacts with other phase II detoxification enzymes such as those in the UDP-glucuronosyltransferase family. Through these pathways SULT1A2 helps transform hydrophobic compounds into more hydrophilic forms aiding in their elimination from the organism. The enzyme's role in hormone homeostasis connects it to pathways involving hormone regulation and action.

SULT1A2 has links to certain cancers and drug metabolism disorders. In cancers altered expression levels of SULT1A2 may affect the balance of hormones potentially contributing to oncogenesis. It has also been noted in disorders of drug metabolism where malfunction of SULT1A2 can impact the efficacy and toxicity of administered medications. The enzyme interacts with cytochrome P450 family proteins which play roles in the metabolic pathways of both drugs and endogenous compounds.
style
left-column

Specifications

Form

Liquid

Additional notes

The purity of ab173058 is geater than 95%, as determined by SEC-HPLC and reducing SDS-PAGE.

style
left-column

General info

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Sequence similarities

Belongs to the sulfotransferase 1 family.

style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
See full target information SULT1A2
style
left-column
style
left-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
style
left-column
style
right-column

Associated Products

Select an associated product type
Alternative Product
Proteins & Peptides

AB109961

Recombinant Human SULT1A2 protein

proteins-peptides

recombinant-human-sult1a2-protein-ab109961

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com