Recombinant Human SULT1B1 protein is a Human Full Length protein, in the 1 to 296 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S H M L S P K D I L R K D L K L V H G Y P M T C A F A S N W E K I E Q F H S R P D D I V I A T Y P K S G T T W V S E I I D M I L N D G D I E K C K R G F I T E K V P M L E M T L P G L R T S G I E Q L E K N P S P R I V K T H L P T D L L P K S F W E N N C K M I Y L A R N A K D V S V S Y Y H F D L M N N L Q P F P G T W E E Y L E K F L T G K V A Y G S W F T H V K N W W K K K E E H P I L F L Y Y E D M K E N P K E E I K K I I R F L E K N L N D E I L D R I I H H T S F E V M K D N P L V N Y T H L P T T V M D H S K S P F M R K G T A G D W K N Y F T V A Q N E K F D A I Y E T E M S K T A L Q F R T E I
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440).
Alternative names
ST1B2, SULT1B2, SULT1B1, Sulfotransferase 1B1, ST1B1, Sulfotransferase 1B2, Sulfotransferase family cytosolic 1B member 1, Thyroid hormone sulfotransferase
Recommended products
Recombinant Human SULT1B1 protein is a Human Full Length protein, in the 1 to 296 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- O43704-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S H M L S P K D I L R K D L K L V H G Y P M T C A F A S N W E K I E Q F H S R P D D I V I A T Y P K S G T T W V S E I I D M I L N D G D I E K C K R G F I T E K V P M L E M T L P G L R T S G I E Q L E K N P S P R I V K T H L P T D L L P K S F W E N N C K M I Y L A R N A K D V S V S Y Y H F D L M N N L Q P F P G T W E E Y L E K F L T G K V A Y G S W F T H V K N W W K K K E E H P I L F L Y Y E D M K E N P K E E I K K I I R F L E K N L N D E I L D R I I H H T S F E V M K D N P L V N Y T H L P T T V M D H S K S P F M R K G T A G D W K N Y F T V A Q N E K F D A I Y E T E M S K T A L Q F R T E I
- Accession
- O43704
- Protein length
- Full Length
- Predicted molecular weight
- 37.4 kDa
- Amino acids
- 1 to 296
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
purified by using conventional chromatography techniques.
General info
- Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440).
- Sequence similarities
Belongs to the sulfotransferase 1 family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SULT1B1 also known as Sulfotransferase Family 1B Member 1 is an enzyme that belongs to the sulfotransferase family. It has a molecular weight of approximately 34 kDa. This enzyme is mainly expressed in the liver and small intestine with some presence in the colon and brain. SULT1B1 participates in the sulfation process where it transfers a sulfo group to phenolic compounds aiding in their metabolism and detoxification.
- Biological function summary
Sulfotransferases like SULT1B1 are essential for the modulation and detoxification of hormones drugs and xenobiotics. This process plays an important role in maintaining balance within the body. While not known to form part of large complexes SULT1B1 works individually on its substrates altering their biological activity and solubility. This metabolic function ensures regulated activity and excretion of various compounds from the body.
- Pathways
SULT1B1 participates in both xenobiotic metabolism and hormone regulation pathways. In the context of xenobiotic metabolism SULT1B1 alongside enzymes like Cytochrome P450s carries out phase II reactions facilitating the elimination of foreign compounds from the body. In hormone regulation SULT1B1's function is to inactivate hormones such as thyroid hormones rendering them less active and promoting their clearance from circulation.
- Associated diseases and disorders
Aberrant activity or expression of SULT1B1 might relate to colorectal cancer and thyroid hormone imbalances. Altered sulfotransferase activity affects hormone regulation contributing to disorders like hypothyroidism. Additionally disruptions may link to other pathways involving proteins such as deiodinases in thyroid regulation emphasizing the importance of balanced sulfation activity in maintaining hormone homeostasis and preventing disease development.
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1 product image
SDS-PAGE - Recombinant Human SULT1B1 protein (ab126691)
15% SDS-PAGE using 3µg of ab126691.
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