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AB102759

Recombinant Human SULT1C2 protein

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Recombinant Human SULT1C2 protein is a Human Full Length protein, in the 1 to 296 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

SULT1C1, SULT1C2, Sulfotransferase 1C2, ST1C2, Sulfotransferase 1C1, humSULTC2, SULT1C#1

1 Images
SDS-PAGE - Recombinant Human SULT1C2 protein (AB102759)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SULT1C2 protein (AB102759)

15% SDS-PAGE showing ab102759 at approximately 37.0kDa (3µg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

O00338

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL","proteinLength":"Full Length","predictedMolecularWeight":"37 kDa","actualMolecularWeight":null,"aminoAcidEnd":296,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O00338","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SULT1C2 also known as sulfotransferase family 1C member 2 is an enzyme that catalyzes the sulfonation of molecules. It belongs to the sulfotransferase family and exhibits a molecular mass of approximately 34.2 kDa. This enzyme primarily expresses in human tissues with notable expression in the liver intestine and fetal tissues. SULT1C2 adds sulfonate groups to hydroxyl groups on substrates which influences the molecules’ activity and solubility.
Biological function summary

Sulfotransferase family 1C member 2 participates in the metabolism and detoxification of hormones neurotransmitters and xenobiotics. This enzyme does not typically function as part of a larger protein complex but acts individually to modify and regulate the activity and excretion of its substrates. Through sulfonation SULT1C2 contributes to the regulation of hormone activity and assists in the chemical defense mechanism of the organism by aiding the elimination of potential toxins.

Pathways

The activity of SULT1C2 plays a significant role in the sulfation pathway. It is important in the modification process which affects molecules in the metabolism particularly those involved in drug metabolism and the detoxification processes. SULT1C2 interacts with other enzymes from the sulfotransferase family that also contribute to these metabolic pathways such as SULT1A1 and SULT1E1.

Improper function or regulation of sulfotransferase family 1C member 2 has connections with certain cancers and liver disorders. Abnormal sulfonation by SULT1C2 may impact hormone regulation which relates to proliferative diseases like breast cancer. Furthermore liver disorders can arise when detoxification processes are impaired. Other sulfotransferases like SULT1A1 often show similar associations with these conditions highlighting a broader relationship between sulfonation activity and disease states.
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Specifications

Form

Liquid

Additional notes

purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.

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General info

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed : 10481272, PubMed : 10783263, PubMed : 9852044). Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed : 9852044).

Sequence similarities

Belongs to the sulfotransferase 1 family.

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Product protocols

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Target data

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed : 10481272, PubMed : 10783263, PubMed : 9852044). Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed : 9852044).
See full target information SULT1C2
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