Recombinant Human Superoxide Dismutase 3/EC-SOD protein (His tag) is a Human Full Length protein, in the 19 to 240 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE
No
W T G E D S A E P N S D S A E W I R D M Y A K V T E I W Q E V M Q R R D D D G A L H A A C Q V Q P S A T L D A A Q P R V T G V V L F R Q L A P R A K L D A F F A L E G F P T E P N S S S R A I H V H Q F G D L S Q G C E S T G P H Y N P L A V P H P Q H P G D F G N F A V R D G S L W R Y R A G L A A S L A G P H S I V G R A V V V H A G E D D L G R G G N Q A S V E N G N A G R R L A C C V V G V C G P G L W E R Q A R E H S E R K K R R R E S E C K A A
Application | Reactivity | Dilution info | Notes |
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Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Extracellular superoxide dismutase [Cu-Zn], EC-SOD, SOD3
Recombinant Human Superoxide Dismutase 3/EC-SOD protein (His tag) is a Human Full Length protein, in the 19 to 240 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE
No
No
Human
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
W T G E D S A E P N S D S A E W I R D M Y A K V T E I W Q E V M Q R R D D D G A L H A A C Q V Q P S A T L D A A Q P R V T G V V L F R Q L A P R A K L D A F F A L E G F P T E P N S S S R A I H V H Q F G D L S Q G C E S T G P H Y N P L A V P H P Q H P G D F G N F A V R D G S L W R Y R A G L A A S L A G P H S I V G R A V V V H A G E D D L G R G G N Q A S V E N G N A G R R L A C C V V G V C G P G L W E R Q A R E H S E R K K R R R E S E C K A A
Full Length
28.1 kDa
19 to 240
Recombinant
His tag N-Terminus
Liquid
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Belongs to the Cu-Zn superoxide dismutase family.
Blue Ice
-20°C
-20°C
Avoid freeze / thaw cycle
Previously labelled as Superoxide Dismutase 3.
This supplementary information is collated from multiple sources and compiled automatically.
Superoxide Dismutase 3 also known as EC-SOD is an antioxidant enzyme with a molecular weight of approximately 135 kDa. It's an extracellular enzyme that catalyzes the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen. EC-SOD is found mostly in the extracellular matrix tissues such as lungs blood vessels and heart. Its activity depends on the presence of metal ions copper and zinc leading its classification as a Cu/Zn SOD enzyme. Scientists often study EC-SOD using ELISA assays because of its importance in neutralizing reactive oxygen species.
The enzyme acts as an important regulator of oxidative stress by reducing levels of superoxide radicals. EC-SOD forms a complex with heparan sulfate proteoglycans in the extracellular matrix which influences its stability and distribution. This enzyme plays a role in maintaining the redox balance influencing cell signaling inflammation and tissue damage which makes it important in managing oxidative stress in different tissues including the cardiovascular and respiratory systems.
Superoxide dismutase 3 participates in antioxidant pathways important for cellular defense against oxidative stress. It is particularly important in the oxidative stress response pathway. By reducing superoxide radicals EC-SOD influences pathways involving other antioxidant proteins like catalase and glutathione peroxidase. These interactions help prevent the accumulation of harmful oxidants and maintain cellular homeostasis. EC-SOD's action connects closely with other superoxide dismutases such as Cu/Zn SOD and MnSOD within these protective pathways.
Enhanced or impaired EC-SOD function associates with various health issues such as cardiovascular diseases and chronic obstructive pulmonary disease (COPD). EC-SOD has been shown to protect vascular health by reducing oxidative stress related damages which can mitigate the risk of atherosclerosis. In the context of respiratory conditions like COPD alterations in EC-SOD expression can disrupt lung tissue function and inflammatory responses. Its interactions with proteins like catalase further contribute to its protective role against cell and tissue damage during disease progression.
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(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab236182.
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