Recombinant Human Superoxide Dismutase 4/CCS protein (His tag N-Terminus)
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Recombinant Human Superoxide Dismutase 4/CCS protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 274 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
Copper chaperone for superoxide dismutase, Superoxide dismutase copper chaperone, CCS
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Superoxide Dismutase 4/CCS protein (His tag N-Terminus) (AB99300)
15% SDS-PAGE showing ab299300 (3μg).
Complementary Products
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CCS contributes significantly to oxidative stress response by catalyzing the dismutation of superoxide radicals into less reactive molecular oxygen and hydrogen peroxide. This protein does not function independently but is part of a complex system involving SOD1 to mitigate oxidative damage within cells. CCS ensures SOD1 acquires the necessary copper which is essential for its dismutase activity hence playing a critical role in maintaining cellular health.
Pathways
The copper delivery to SOD1 by CCS integrates into the broader antioxidant defense pathway. The copper chaperones like CCS link to pathways involving cellular copper homeostasis and oxidative stress management. The protein SOD1 which relies on CCS for copper addition also aligns with the apoptosis and neuroprotective pathways highlighting a shared role in cellular oxidation states control and maintaining neuronal integrity.
Specifications
Form
Liquid
Additional notes
ab99300 is purified using conventional chromatography techniques.
General info
Function
Delivers copper to copper zinc superoxide dismutase (SOD1).
Sequence similarities
In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.
Post-translational modifications
Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241.
Target data
Product promise
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