Recombinant Human Surb7 protein is a Human Full Length protein, in the 1 to 144 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M A D R L T Q L Q D A V N S L A D Q F C N A I G V L Q Q C G P P A S F N N I Q T A I N K D Q P A N P T E E Y A Q L F A A L I A R T A K D I D V L I D S L P S E E S T A A L Q A A S L Y K L E E E N H E A A T C L E D V V Y R G D M L L E K I Q S A L A D I A Q S Q L K T R S G T H S Q S L P D S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Alternative names
SRB7, SURB7, MED21, Mediator of RNA polymerase II transcription subunit 21, Mediator complex subunit 21, RNA polymerase II holoenzyme component SRB7, RNAPII complex component SRB7, hSrb7
Recommended products
Recombinant Human Surb7 protein is a Human Full Length protein, in the 1 to 144 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q13503-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M A D R L T Q L Q D A V N S L A D Q F C N A I G V L Q Q C G P P A S F N N I Q T A I N K D Q P A N P T E E Y A Q L F A A L I A R T A K D I D V L I D S L P S E E S T A A L Q A A S L Y K L E E E N H E A A T C L E D V V Y R G D M L L E K I Q S A L A D I A Q S Q L K T R S G T H S Q S L P D S
- Accession
- Q13503
- Protein length
- Full Length
- Predicted molecular weight
- 18 kDa
- Amino acids
- 1 to 144
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab156980 is purified using conventional chromatography techniques.
General info
- Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
- Sequence similarities
Belongs to the Mediator complex subunit 21 family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein Surb7 also known as ALMS3 is a significant part of molecular machinery. This protein has an approximate mass of 85 kDa. Researchers identify its presence mostly in the kidney liver and lungs suggesting a role closely tied to physiological processes in these organs. Structurally Surb7 consists of several domains that collaborate in its function related to cellular structure and signaling.
- Biological function summary
Surb7 influences the organization and function of cellular structures. It associates with multi-protein complexes that stabilize intracellular scaffolding. This protein contributes to cellular homeostasis aiding in maintaining the shape and integrity of cells. Surb7's activity supports critical cellular processes such as transport across cell membranes and interactions between cellular compartments.
- Pathways
Interactions between Surb7 and other cellular components indicate its role in signaling and structural regulation. It prominently participates in the mTOR signaling pathway a central pathway for cell growth and metabolism. Additionally Surb7 interacts with the MAPK cascade which is fundamental to cellular responses to stimuli. These pathways connect Surb7 with proteins like PI3K and ERK facilitating regulation of cell survival and proliferation.
- Associated diseases and disorders
Research suggests a connection between Surb7 mutations and certain disorders. Patients with Alström syndrome a condition characterized by multisystemic symptoms exhibit aberrant Surb7 function. The protein's role in Alström syndrome likely involves altered interactions with key players such as ALMS1. Furthermore abnormal expression of Surb7 has been observed in cases of some renal disorders implicating a potential link with kidney-specific protein dysfunctions.
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1 product image
SDS-PAGE - Recombinant Human Surb7 protein (ab156980)
15% SDS-PAGE analysis of ab156980 (3μg).
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