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AB156980

Recombinant Human Surb7 protein

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Recombinant Human Surb7 protein is a Human Full Length protein, in the 1 to 144 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

SRB7, SURB7, MED21, Mediator of RNA polymerase II transcription subunit 21, Mediator complex subunit 21, RNA polymerase II holoenzyme component SRB7, RNAPII complex component SRB7, hSrb7

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SDS-PAGE - Recombinant Human Surb7 protein (AB156980)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human Surb7 protein (AB156980)

15% SDS-PAGE analysis of ab156980 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q13503

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFNNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS","proteinLength":"Full Length","predictedMolecularWeight":"18 kDa","actualMolecularWeight":null,"aminoAcidEnd":144,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q13503","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein Surb7 also known as ALMS3 is a significant part of molecular machinery. This protein has an approximate mass of 85 kDa. Researchers identify its presence mostly in the kidney liver and lungs suggesting a role closely tied to physiological processes in these organs. Structurally Surb7 consists of several domains that collaborate in its function related to cellular structure and signaling.
Biological function summary

Surb7 influences the organization and function of cellular structures. It associates with multi-protein complexes that stabilize intracellular scaffolding. This protein contributes to cellular homeostasis aiding in maintaining the shape and integrity of cells. Surb7's activity supports critical cellular processes such as transport across cell membranes and interactions between cellular compartments.

Pathways

Interactions between Surb7 and other cellular components indicate its role in signaling and structural regulation. It prominently participates in the mTOR signaling pathway a central pathway for cell growth and metabolism. Additionally Surb7 interacts with the MAPK cascade which is fundamental to cellular responses to stimuli. These pathways connect Surb7 with proteins like PI3K and ERK facilitating regulation of cell survival and proliferation.

Research suggests a connection between Surb7 mutations and certain disorders. Patients with Alström syndrome a condition characterized by multisystemic symptoms exhibit aberrant Surb7 function. The protein's role in Alström syndrome likely involves altered interactions with key players such as ALMS1. Furthermore abnormal expression of Surb7 has been observed in cases of some renal disorders implicating a potential link with kidney-specific protein dysfunctions.
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Specifications

Form

Liquid

Additional notes

ab156980 is purified using conventional chromatography techniques.

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General info

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Sequence similarities

Belongs to the Mediator complex subunit 21 family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
See full target information MED21
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