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AB159616

Recombinant Human SURF4 protein (GST tag N-Terminus)

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Recombinant Human SURF4 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 269 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

SURF-4, SURF4, Surfeit locus protein 4

1 Images
SDS-PAGE - Recombinant Human SURF4 protein (GST tag N-Terminus) (AB159616)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SURF4 protein (GST tag N-Terminus) (AB159616)

ab159616 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

O15260

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB133369

Anti-SURF4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SURF4 antibody (AB133369)

  • 0
  • 0
Cell Lines & Lysates

AB266463

Human SURF4 knockout HEK-293T cell line

Sanger Sequencing - Human SURF4 knockout HEK-293T cell line (AB266463)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB76109

Anti-MMP20 antibody [EP1275Y]

RabMAb|Recombinant

Western blot - Anti-MMP20 antibody [EP1275Y] (AB76109)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKEW","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":269,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O15260","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SURF4 also known as Surfeit locus protein 4 is a membrane protein with a molecular mass of approximately 30 kDa. It functions mechanically as part of the endoplasmic reticulum membrane and plays a role in protein transport. SURF4 facilitates the movement of specific proteins between the endoplasmic reticulum and the Golgi apparatus. This protein exhibits broad expression being present in various tissues including liver and kidney.
Biological function summary

The functions of SURF4 integrate into cellular processes through its involvement in protein secretion and sorting pathways. SURF4 participates as part of a complex that mediates the trafficking of glycoproteins which are essential for numerous cellular activities. The protein assists in the maintenance of quality control within the secretory pathway and ensures that proteins reach their correct destinations which is critical for proper cell function.

Pathways

SURF4 engages actively in processes related to protein transport and glycoprotein trafficking. It participates in the secretory pathway ensuring efficient delivery of proteins to the Golgi apparatus. The protein relates closely to other endoplasmic reticulum proteins like EMC1 which is involved in the coordinated movement and processing of proteins within the cell. SURF4's role intertwines with these components influencing cellular homeostasis and protein synthesis.

SURF4 interlinks with health issues involving protein misfolding and secretion defects. Mutations or dysregulation can lead to conditions like congenital disorders of glycosylation characterized by defects in glycoprotein synthesis and processing. Dysregulation of SURF4 activity may also impact hepatic steatosis as SURF4 is implicated in lipid metabolism. The interaction with proteins like SEC61 which aids in protein translocation highlights its importance in maintaining cellular balance and reducing disease risk.
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Specifications

Form

Liquid

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General info

Function

Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed : 29643117, PubMed : 30251625, PubMed : 33186557). Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed : 29643117, PubMed : 33186557). Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins (PubMed : 33186557). Promotes the secretion of PCSK9 (PubMed : 30251625). Also mediates the efficient secretion of erythropoietin (EPO) (PubMed : 32989016). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi (PubMed : 18287528).

Sequence similarities

Belongs to the SURF4 family.

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Product protocols

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Target data

Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed : 29643117, PubMed : 30251625, PubMed : 33186557). Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed : 29643117, PubMed : 33186557). Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins (PubMed : 33186557). Promotes the secretion of PCSK9 (PubMed : 30251625). Also mediates the efficient secretion of erythropoietin (EPO) (PubMed : 32989016). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi (PubMed : 18287528).
See full target information SURF4
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