Recombinant Human SUV420h1 protein
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant Human SUV420h1 protein is a Human Fragment protein, in the 2 to 387 aa range, expressed in Escherichia coli, with >20%, suitable for SDS-PAGE.
View Alternative Names
SUV420H1, CGI-85, KMT5B, Histone-lysine N-methyltransferase KMT5B, Lysine N-methyltransferase 5B, Lysine-specific methyltransferase 5B, Suppressor of variegation 4-20 homolog 1, [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B, [histone H4]-lysine20 N-methyltransferase KMT5B, Su(var)4-20 homolog 1, Suv4-20h1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human SUV420h1 protein (AB80286)
SDS-PAGE showing ab80286 at approximately 70kDa (3μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SUV420h1 modifies chromatin structure and affects gene transcription. It participates in forming a trimethylation complex with other proteins contributing to heterochromatin formation. This process controls the access of transcriptional machinery to DNA influencing gene silencing and activation. SUV420h1 plays a significant role in maintaining genome stability by regulating chromosome segregation during cell division.
Pathways
SUV420h1 serves a function in the DNA damage response and cell cycle regulation. It interacts with proteins involved in the ATR-Chk1 pathway which is important for responding to DNA damage and faulty replication. SUV420h1 also works with HP1 proteins in pathways that ensure proper chromatin structure thereby maintaining nuclear architecture and integrity.
Specifications
Form
Liquid
General info
Function
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed : 24396869, PubMed : 28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed : 24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed : 23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed : 28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
Sequence similarities
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com